Biaven V.i.

Biaven V.I.

Country of origin: Italy
Pharm-Group: Immunoglobulins

Manufacturers: Pharma Biagini (Italy)
International name: Normal human immunoglobulin
Synonyms: Venoglobulin, Gabriglobin, Gamimun N, I.G. Vienna N.I.V., Imbiogam, Imbioglobulin, Immunovenin, Immunoglobulin, Normal human immunoglobulin, Intraglobin, Octagam, Sandoglobulin, Humaglobin, Cytotect, Endobulin S/D
Dosage forms: lyophilized powder for the preparation of injection solution 2.5g, lyophilized powder for the preparation of injection solution 1g
Composition: Active ingredient - Normal human immunoglobulin.

Indications for use: Replacement therapy for the prevention of infections in primary immunodeficiency syndromes: agammaglobulinemia, common variable immunodeficiencies associated with a- or hypogammaglobulinemia; deficiency of IgG subclasses, replacement therapy to prevent infections in secondary immunodeficiency syndrome caused by chronic lymphocytic leukemia, AIDS in children or bone marrow transplantation, idiopathic thrombocytopenic purpura, Kawasaki syndrome (in addition to treatment with acetylsalicylic acid), severe bacterial infections, including sepsis (in combinations with antibiotics) and viral infections, prevention of infections in premature infants with low birth weight (less than 1500 g), Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy, autoimmune neutropenia, partial red cell aplasia of hematopoiesis, thrombocytopenia of immune origin, incl. h. post-transfusion purpura, isoimmune thrombocytopenia of newborns, hemophilia caused by the formation of antibodies to coagulation factors, myasthenia gravis, prevention and treatment of infections during therapy with cytostatics and immunosuppressants, prevention of recurrent miscarriage.

Contraindications: Hypersensitivity to human immunoglobulins, especially in patients with IgA deficiency due to the formation of antibodies to it.

Side effects: Headache, nausea, dizziness, vomiting, abdominal pain, diarrhea, arterial hypo- or hypertension, tachycardia, cyanosis, shortness of breath, feeling of constriction or pain in the chest, allergic reactions; rarely - severe hypotension, collapse, loss of consciousness, hyperthermia, chills, increased sweating, fatigue, malaise, back pain, myalgia, numbness, hot flashes or a feeling of cold.

Interactions: May reduce the effectiveness of active immunization: parenteral live viral vaccines should not be used for at least 30 days after immunoglobulin administration.

Overdose: No data available.

Special instructions: Most side effects are associated with a high rate of infusion and can be managed by stopping or slowing down the infusion. If severe side effects occur, administration should be discontinued (adrenaline, antihistamines, corticosteroids and plasma expanders may be indicated). If renal function is impaired, it is recommended to monitor the condition of patients during treatment (monitor creatinine within 3 days after infusion). After the administration of immunoglobulin, the content of antibodies in the blood increases (passively), which can lead to erroneous interpretation of the results of a serological test.

Literature: Encyclopedia of Medicines 2004