Enterop atic acrodermatitis (Brandt's syndrome, Danbolt-Kloss syndrome)

Acrodermatitis Enteropathica (Brandt Syndrome, Danbolt-Kloss Syndrome)

Acrodermatitis enteropathica (Brandt syndrome, Danbolt-Kloss syndrome) is a disease of infants that coincides with the onset of complementary feeding.

Etiology and pathogenesis. The disease is based on zinc deficiency in the body due to its insufficient intake from food or impaired absorption in the intestines. Zinc deficiency reduces the activity of many enzymes and underlies metabolic disorders, especially carbohydrates and proteins.

Clinical picture. Vesicular, pustular, bullous dermatitis of the distal parts of the extremities, around the natural orifices of the body, often alopecia, loss of eyebrows and eyelashes, damage to the mucous membranes by yeast-like fungi, gastrointestinal disorders (diarrhea, steatorrhea, profuse bowel movements with an unpleasant odor) are observed.

Subsequently, malnutrition, secondary purulent infection, and growth retardation develop. The diagnosis is confirmed by identifying low levels of zinc in the blood. A differential diagnosis with impaired intestinal absorption syndrome and dermatitis is necessary.

Treatment consists of prescribing zinc sulfate up to 100-150 mg/day for 2-3 months, and enzyme preparations. With early recognition and treatment, the prognosis is favorable.

Prevention of the disease consists of following the rules of feeding children in accordance with their age.