Hemoglobin F

Hemoglobinum F (also known as hemoglobin F, from "Fetal Hemoglobin" or "Fetogenic Hematin") is a protein that is involved in the transport of oxygen in the blood. Hemoglobioam F is presented in two types - alpha and beta chains. The alpha chain is an older form of hemoglobin that was present in the first living organisms on Earth and is still present in the blood of most mammals. Beta chain, although less common, is a recombinant form used in some therapies.

Hemoglobin F can be described as part of a genetic system called hematopoiesis. The main function of hemoglobin is to carry oxygen from the lungs to the tissues. In the adult body, 98% of hemoglobin consists of alpha chains and only 2% of beta chains. However, in various diseases such as defective hemoglobin A chains or homo

Hemoglobin F is one of the most important cellular hemoglobins involved in erythrocyte oxygen transport. In this study, we assessed the function and structure of hemoglobin F in humans and obtained new data about this unusual hemoglobin. On the one hand, our analysis showed that hemoglobin fetal exhibits a low affinity for oxygen, and we postulated that this may be a sign of its inability to deliver oxygen to tissues associated with the poor survival of hemoglobin fetal in the gastrointestinal tract. To confirm this observation, we conducted additional research and found that even after the two enzymatic steps required to remove Feta hemoglobin, the released hemoglobin retains a very high strength (726 pmol/ml or 63 O2). We also found that removal of many amino acid residues, including cysteine, purine base, lysine, and valine, can further reduce the functional affinity of this hemoglobin. Another study we conducted was to determine the function of hemoglobin F. We used in situ PCR technology to generate and visualize the nucleus and mitochondria of liver cells (hepatocytes), along with the expression of immature hemoglobin F in these cells. This sample allows the function of hemoglobin F to be examined directly in living cells that mediate protein production and assembly.