Leishmaniasis American

Leishmaniasis, or Niemann-Pick disease, is caused by human infection with a rare species of leishmania - L. (Leishmania) donovani, which is transmitted through the bite of midges and penetrates the liver, spleen, and lymph nodes. The syndrome is quite common among newborns in developed countries, especially in America, and occurs due to a lack of lysosomal acid phosphatase, which catabolizes cholesterol. Cholesterol concentrations in liver cells are reduced due to deficiency of the enzyme adenine penicillamine phosphorylase.