Lymphoma Malignant

Lymphomas are a large group of malignant tumors of the lymphatic system that affect leukopoiesis cells, B and T lymphocytes, histiocytes and other lymphocyte populations. The incidence of lymphoid malignancy is about 3% of all malignant neoplasms, and according to some data reaches 5%.

Lymphomas represent a serious clinical problem, since for successful treatment it is necessary to suppress tumor growth in the lymph nodes and specific foci in the body. With late presentation and inadequate treatment, patients die in a short time. Classic lymphoma is one of the top ten malignant human diseases. This is due to a fairly high percentage of cases ending in recovery or a long period of remission.

History of the disease According to the latest data, lymphoma was first isolated and cultured on chicken embryos under a microscope at the beginning of the 20th century. In the 80s of the last century, close attention began to be paid to the immunological and molecular control of lymphomas, which made it possible to more accurately determine their type. These studies are still ongoing. Clinical signs and symptoms of the disease are found in both Hodgkin lymphoma and malignant lymphoma. This is one of the youngest sections of oncomorphology; its study began only in the 60s of the last century. Classification Depending on the structure and number of cells, several forms of classical lymphoma are distinguished, differing in biology and prognosis for patients: * differentiated variant, or lymphoid malignancy of the tissue; in this variety there is an increase in proliferating cells predominantly from mature lymphocytes; * malignant lymphoma, accompanied by an increase in the number of stem cells producing defective and altered lymphocytes; these lymphoid neoplasms have a tendency to metastasize and recur; * its diffuse subtype is a eurymorphic form, characterized by the progressive growth of mature cells of different zones of lymphoid hematopoiesis; indolent form, which is quite rare; it is characterized by slow development over a long period of time