Schilder's Disease

Schilder's disease, also known as diffuse axonal aplasia extracortical (DADE), is a rare disorder of the nervous system that is characterized by damage to axons and interglobular spaces. This can lead to a variety of symptoms, including blurred vision, loss of coordination, seizures and other neurological problems.

The disease was first described in 1928 by the American neuropathologist and psychiatrist Paul Friedrich Schilder (1886–1940). He also proposed several synonyms for this disease, including periaxial diffuse leukoencephalitis, symmetrical interglobular sclerosis, and diffuse sclerosis of the nervous system.

Schilder's disease usually appears between the ages of 20 and 40, although it can occur in children. Symptoms may include blurred vision, seizures, headaches, muscle weakness, poor coordination and decreased intelligence. Some patients may also experience sleep disturbances, depression and anxiety.

Diagnosis of Schilder's disease is based on an analysis of clinical symptoms, as well as on the results of magnetic resonance imaging (MRI) and electroencephalography. Treatment may include anticonvulsant medications such as carbamazepine or valproic acid, as well as physical therapy and psychotherapy.

Overall, Schilder's disease is a rare but serious disorder of the nervous system. Its diagnosis and treatment require an integrated approach and careful monitoring by specialists.

"Schilder's syndrome" is a condition of multiple sclerosis (MS) that results in infiltration of inflammatory and necrotic tissue in several parts of the brain or spinal cord.

Schilder was the first scientist to describe MS. He did this in his famous article "Syphilis, Vodka Psycho