What does Thiogamma help with?

Thiogamma: instructions for use and reviews

Latin name: Thiogamma

ATX code: A16AX01

Active ingredient: Thioctic acid

Manufacturer: Verwag Pharma GmbH and Co. KG (Worwag Pharma GmbH & Co. KG), Böblingen, Germany

Update of description and photo: 05/02/2018

Prices in pharmacies: from 186 rubles.

Thiogamma is a drug that regulates lipid and carbohydrate metabolism.

Release form and composition

1. solution for infusion: transparent, light yellow or yellowish-green (50 ml in a dark glass bottle, 1 or 10 bottles in a cardboard box);
2. concentrate for the preparation of a solution for infusion: a transparent yellowish-green solution (20 ml in a dark glass ampoule, 5 ampoules in a tray, 1, 2 or 4 trays in a cardboard box);
3. film-coated tablets: oblong, convex on both sides, light yellow in color with white and yellow inclusions of varying intensity, with marks on both sides; a cross-section shows a light yellow core (10 pieces in a blister, 3, 6 or 10 blisters in a cardboard box).

Active substance – thioctic acid:

1. 1 ml of solution – 12 mg (600 mg in 1 bottle);
2. 1 ml of concentrate – 30 mg (600 mg in 1 ampoule);
3. 1 tablet – 600 mg.

1. solution: macrogol 300, meglumine, water for injection;
2. concentrate: macrogol 300, meglumine, water for injection;
3. tablets: colloidal silicon dioxide, croscarmellose sodium, microcrystalline cellulose, simethicone (dimethicone and colloidal silicon dioxide in a ratio of 94:6), lactose monohydrate, talc, magnesium stearate, hypromellose; shell composition: hypromellose, sodium lauryl sulfate, talc, macrogol 6000.

Pharmacological properties

Pharmacodynamics

The active ingredient of the drug is thioctic (alpha-lipoic) acid. It is an endogenous antioxidant that binds free radicals. Thioctic acid is formed in the body during the oxidative decarboxylation of alpha-keto acids. It is a coenzyme of multienzyme complexes in mitochondria and is involved in the oxidative decarboxylation of alpha-keto acids and pyruvic acid.

Alpha lipoic acid helps reduce blood glucose levels, increase glycogen concentrations in the liver and overcome insulin resistance. According to the mechanism of action, it is close to B vitamins.

Thioctic acid regulates carbohydrate and lipid metabolism, improves liver function and stimulates cholesterol metabolism. It has hypolipidemic, hypoglycemic, hepatoprotective and hypocholesterolemic effects. Helps improve neuron nutrition.

When using the megluminic salt of alpha-lipoic acid (has a neutral reaction) in solutions for intravenous administration, the severity of side effects can be reduced.

Pharmacokinetics

When administered orally, thioctic acid is quickly and completely absorbed from the gastrointestinal tract. When taken simultaneously with food, absorption of the drug is reduced. Bioavailability is 30%. To achieve the maximum concentration of the active substance, it takes from 40 to 60 minutes.

Thioctic acid undergoes a first-pass effect through the liver. Metabolized in two ways: by conjugation and by oxidation of the side chain.

The volume of distribution is approximately 450 ml/kg. Up to 80–90% of the dose taken is excreted by the kidneys in the form of metabolites and unchanged. The half-life ranges from 20 to 50 minutes. The total plasma clearance of the drug is 10–15 ml/min.

The time to reach maximum plasma concentration with intravenous administration of Thiogamma is 10–11 minutes, and the maximum plasma concentration is 25–38 mcg/ml. AUC (area under the concentration-time curve) is approximately 5 mcg/h/ml.

Indications for use

Thiogamma is a drug intended for the treatment of polyneuropathy (diabetic and alcoholic).

Contraindications

1. hereditary galactose intolerance, lactase deficiency or glucose-galactose malabsorption (for tablets);
2. age under 18 years;
3. pregnancy;
4. breastfeeding period;
5. hypersensitivity to the components of the drug.

Instructions for use of Thiogamma: method and dosage

Solution for infusion and concentrate for the preparation of solution for infusion

The solution, including those prepared from concentrate, is administered intravenously.

The daily dose of Thiogamma is 600 mg (1 bottle of solution or 1 ampoule of concentrate).

The drug is administered over 30 minutes (at a rate of about 1.7 ml per minute).

Preparation of a solution from the concentrate: mix the contents of 1 ampoule with 50–250 ml of 0.9% sodium chloride solution. Immediately after preparation, the solution should be immediately covered with the included light-protective case. Store for no more than 6 hours.

When using the prepared solution, remove the bottle from the cardboard packaging and immediately cover it with a light-protective case. The infusion should be carried out directly from the vial.

The duration of treatment is 2–4 weeks. If it is necessary to continue therapy, the patient is transferred to the tablet form of the drug.

Film-coated tablets

The tablets should be taken orally on an empty stomach: swallowed whole and washed down with sufficient liquid.

The recommended dose of Thiogamma is 600 mg (1 tablet) per day.

The duration of treatment, depending on the severity of the disease, is 30–60 days.

If necessary, repeated courses can be conducted 2-3 times a year.

Side effects

Solution and concentrate

Thiogamma is generally well tolerated. Rarely, including isolated cases, the following side effects occur:

1. from the endocrine system: decreased concentration of glucose in the blood (visual disturbances, increased sweating, dizziness, headache);
2. from the central nervous system: disturbance or change in taste sensations, convulsions, epileptic seizure;
3. from the hematopoietic system: hemorrhagic rash (purpura), thrombocytopenia, thrombophlebitis, pinpoint hemorrhages in the skin and mucous membranes;
4. from the skin and subcutaneous tissue: eczema, itching, rash;
5. from the organ of vision: diplopia;
6. allergic reactions: urticaria, systemic reactions (discomfort, nausea, itching) up to the development of anaphylactic shock;
7. local reactions: hyperemia, irritation, swelling;
8. other: in case of rapid administration of the drug - difficulty breathing, increased intracranial pressure (a feeling of heaviness in the head occurs).

Film-coated tablets

Thiogamma is generally well tolerated. Rarely, including isolated cases, the following side effects occur:

1. allergic reactions: urticaria, skin rash, itching, systemic reactions up to the development of anaphylactic shock;
2. from the digestive system: abdominal pain, nausea, diarrhea, vomiting;
3. from the endocrine system: decreased concentration of glucose in the blood (visual disturbances, increased sweating, dizziness, headache).

Overdose

An overdose of thioctic acid causes the following symptoms: headache, nausea and vomiting. When taking 10–40 g of Thiogamma in combination with alcohol, cases of severe intoxication, even death, have been reported.

In case of an acute overdose of the drug, confusion or psychomotor agitation occurs, usually accompanied by lactic acidosis and generalized convulsions. Cases of hemolysis, rhabdomyolysis, hypoglycemia, bone marrow suppression, disseminated intravascular coagulation, multiorgan failure and shock have been described.

Treatment is symptomatic. There is no specific antidote for thioctic acid.

special instructions

Patients with diabetes mellitus during treatment (and especially at the initial stage) need to monitor the concentration of glucose in the blood and, if necessary, adjust the dose of insulin or an oral hypoglycemic drug.

During treatment with Thiogamma, you should not drink alcoholic beverages, since ethanol reduces the therapeutic effect of thioctic acid and promotes the development and progression of neuropathy.

Each tablet contains 49 mg of lactose monohydrate, which corresponds to at least 0.0041 bread units.

Thioctic acid does not affect the ability to operate potentially dangerous machinery or drive a car.

Use during pregnancy and lactation

The drug is prohibited for use in pregnant and lactating women.

Use in childhood

According to the instructions, Tiogamma is contraindicated for children and adolescents under 18 years of age.

Drug interactions

1. ethanol and its metabolites: the effect of thioctic acid is weakened;
2. cisplatin: its effectiveness decreases;
3. glucocorticosteroids: their anti-inflammatory effect is enhanced;
4. insulin, oral hypoglycemic drugs: their effect is enhanced.

Thioctic acid binds metals (iron, magnesium), therefore, if simultaneous use of drugs containing them is necessary, at least 2-hour intervals between doses should be observed.

Thioctic acid reacts with sugar molecules [for example, with a solution of levulose (fructose)], resulting in the formation of sparingly soluble complexes.

In the form of an infusion solution, Thiogamma is incompatible with solutions that react with disulfide and SH groups, Ringer's solution and dextrose solution.

Analogs

Analogues of Thiogamma are the following drugs: Thioctacid BV, Lipoic acid, Thiolepta, Berlition 300, Thioctacid 600T.

Terms and conditions of storage

Store out of reach of children, protected from light, at temperatures up to 25 °C.

Shelf life – 5 years.

Conditions for dispensing from pharmacies

Dispensed by prescription.

Reviews about Tiogamma

The drug is quite often prescribed to patients with diabetes mellitus and a predisposition to polyneuropathy, since it is a good prophylactic agent for diseases of the peripheral nervous system.

Reviews of Thiogamma note that with a relatively short course of treatment, the severe consequences of endocrine diseases can be prevented. The advantage of using the drug is the very rare development of possible side effects.

Experts also speak positively about Thiogamma, noting its therapeutic properties, the rare development of side effects and the low likelihood of overdose.

Allergic skin reactions that may occur during treatment are most often observed in patients with a predisposition. To avoid such reactions, it is recommended to conduct an allergy test before using the drug.

Price for Tiogamma in pharmacies

Prices for Tiogamma in pharmacies:

1. film-coated tablets, 600 mg (30 pieces per package) – from 894 rubles;
2. film-coated tablets, 600 mg (60 pieces per package) – from 1835 rubles;
3. solution for infusion (50 ml bottle, 1 pc.) – from 211 rubles;
4. solution for infusion (50 ml bottle, 10 pcs.) – from 1,784 rubles.
5. concentrate for preparing a solution for infusion (20 ml ampoules, 10 pcs.) – from 1800 rubles.

Various medications can be used to regulate metabolism and treat neuropathy. Doctors often prescribe the drug Thiogamma, which contains thioctic (lipoic, alpha-lipoic) acid, which has properties similar to B vitamins. Reading the instructions for use of the drug will help you obtain information about the indications, side effects, and method of taking the medicine.

Instructions for use of Thiogamma

Thiogamma tablets are drugs that regulate the metabolism of carbohydrates and lipids in the body. This effect is achieved due to the content of lipoic acid. It is one of the substances produced by the body, but if it is deficient, metabolism slows down, and problems such as obesity and diabetes begin. Medicines based on thioctic acid will help in the treatment of these pathologies and polyneuropathy.

Composition and release form

The drug Thiogamma is available in the form of tablets, solution for infusion and concentrate for the preparation of solution for infusion. The tablets are covered with a light yellow shell, with yellow and white inclusions of varying saturation, the shape is oblong and biconvex, there are marks on both sides, and a light yellow tablet core is visible on the cross section. Solution for infusion is yellow-green or light yellow, transparent. The concentrate is a transparent yellow or green-yellow solution in glass ampoules. Composition of the drug:

Thioctic acid 600 mg

Hypromellose, colloidal silicon dioxide, microcrystalline cellulose, lactose monohydrate, carmellose sodium, talc, simethicone, magnesium stearate, macrogol 6000, sodium lauryl sulfate

Meglumine thioctate (equivalent to 600 mg thioctic acid)

Macrogol 300, meglumine, water

Pharmacodynamics and pharmacokinetics

The active ingredient of the drug is thioctic acid, which belongs to the category of endogenous antioxidants that bind free radicals. Inside the human body, it appears in the process of oxidative decarboxylation of alpha-keto acids. The medication has a metabolic and antioxidant effect, lowers blood sugar levels, increases glycogen reserves in the liver and reduces insulin resistance.

Taking Thiogamma affects carbohydrate and lipid metabolism, stimulates liver function and blood circulation, affects cholesterol metabolism, and removes toxins in case of poisoning with heavy metal salts. The medication combines hypoglycemic and hypocholesterolemic effects, is a hepatoprotector, and optimizes neuronal trophism. Taking thioctic acid reduces the level of glycation products, stimulates endoneurial blood flow, increases glutathione levels, providing improvement in the condition of peripheral nerve fibers in diabetic polyneuropathy.

The medication is completely absorbed in the gastrointestinal tract in a short period. Taking it with food reduces its absorption. Metabolism of Thiogamma occurs in the liver through side chain oxidation followed by conjugation. The drug is excreted mainly by the kidneys (up to 90%). The half-life of the substance is about 25 minutes. A minimal amount of the drug components may be found unchanged in the urine.

Indications for use

Thiogamma has indications for use due to the properties of the active substance of the drug. The main reasons for prescribing the drug:

1. neuropathy due to diabetes;
2. painful conditions of the liver: fatty degeneration processes of hepatocytes, cirrhosis and hepatitis of various origins;
3. destruction of nerve trunks caused by alcohol;
4. poisoning with severe symptoms (mushrooms, heavy metal salts);
5. sensorimotor or peripheral polyneuropathy.

Directions for use and dosage

Depending on the form of the drug, the method of administration and dosage differ. It is especially important to follow the rules when using the solution and concentrate to prepare the solution. After removing the bottle from the box, it is necessary to immediately cover it with the included light-protective case (light has a destructive effect on thioctic acid). A solution is prepared from the concentrate: the contents of one ampoule are mixed with 50-250 ml of 0.9% sodium chloride solution. It is recommended to administer the drug immediately, the maximum storage period is 6 hours.

Thiogamma tablets

The tablets are taken once a day before meals at the dosage prescribed by the doctor; the tablets are not chewed and washed down with a small amount of liquid. The duration of the course of therapy is 30-60 days and depends on the severity of the disease. It is permissible to repeat the course of therapy two to three times during the year.

Thiogamma for IVs

When using the drug, it is important to remember to use a light-protective case after removing the bottle from the box. The infusion must be carried out at an injection rate of 1.7 ml per minute. When administered intravenously, it is necessary to maintain a slow pace (period of 30 minutes), a dosage of 600 mg per day. The course of treatment is two to four weeks, after which it is possible to continue taking the drug in oral tablet form at the same daily dosage of 600 mg.

For facial skin

The drug Thiogamma has found its application for facial care. For this purpose, the contents of dropper bottles are used. The use of this form is due to the optimal concentration of the drug. The drug in ampoules is not suitable due to the high density of the active substance, this can cause an allergic reaction. The solution from the bottles must be applied twice a day - morning and evening. Before use, you need to wash your face with warm water (possibly with lotion) to soften the pores and deep penetration of the active ingredient.

special instructions

Among the sections of the instructions for use, the special instructions paragraph deserves close study. It contains rules and recommendations for using the drug:

1. The medication is prohibited for use by patients with fructose intolerance, glucose-galactose malabsorption syndrome, and glucose-isomaltase deficiency.
2. In case of diabetes mellitus, at the beginning of therapy, blood glucose levels should be carefully monitored; sometimes dose adjustment of insulin and other hypoglycemic agents is required. One tablet contains less than 0.0041 bread units.
3. During treatment you should refrain from drinking alcohol. This reduces the therapeutic effect and may cause progression of neuropathy.
4. During treatment, you can operate dangerous machinery and vehicles. The drug does not impair concentration and clarity of vision.

During pregnancy

Due to the content of active substances, the use of Thiogamma during pregnancy and lactation is prohibited. This is associated with a high risk of disruption of the vital functions of the fetus and the development of the infant or newborn. If it is impossible to stop using the drug during lactation, then it is necessary to stop or stop breastfeeding to avoid harm to the baby.

In childhood

The drug is prohibited for use by people under 18 years of age. This is due to the increased effect of thioctic acid on metabolism, which can lead to uncontrollable consequences in the body in children and adolescents. Before use, you should definitely consult a doctor and obtain permission after a thorough examination of your organs and systems.

Thiogamma for weight loss

Lipoic acid is an antioxidant, accelerates metabolic processes, improves the functioning of the pancreas, so it can be used for weight loss. It regulates sugar levels, slows down the aging process, improves blood flow, accelerates the process of converting carbohydrates into energy, and promotes the oxidation of fatty acids. The acid also blocks an enzyme in brain cells that is responsible for sending hunger signals, which helps control appetite.

As we age, the production of lipoic acid slows down, so it is used as a continuous supplement. The drug Tiogamma can be used for weight loss, but subject to regular physical activity. Nutritionists advise taking 600 mg of the active ingredient/day before or after breakfast, along with carbohydrates, after training or with the last meal. At the same time as taking it, you should reduce the caloric content of food consumed.

Drug interactions

Thioctic acid in Thiogamma enhances the anti-inflammatory effect of glucocorticosteroids. Other examples of drug interactions:

1. The drug reduces the effectiveness of Cisplatin.
2. The active substance binds metals, so the simultaneous use of iron, calcium and magnesium supplements is prohibited - at least two hours must pass between the use of these drugs.
3. The medication enhances the effect of insulin and oral hypoglycemic agents.
4. Ethanol and metabolites weaken the effect of the acid.

Side effects

While taking Thiogamma, various side effects may occur. The most common ones include:

1. nausea, diarrhea, vomiting, stomach pain, hepatitis, gastritis;
2. intracranial hemorrhage;
3. respiratory disorders, shortness of breath;
4. allergic reactions, anaphylactic shock, skin rash, itching, urticaria;
5. disturbance of taste sensations;
6. decreased concentration of glucose in the blood - hypoglycemia: dizziness, headache, increased sweating, blurred vision.

Overdose

Symptoms of an overdose of Thiogamma are headache, vomiting, nausea. Acute overdose is manifested by confusion, psychomotor agitation, generalized convulsions, and the formation of lactic acidosis. Sometimes shock, hemolysis, intravascular coagulation, and bone marrow suppression may occur. Taking 10-40 g of thioctic acid in combination with alcohol leads to multiple organ failure, intoxication, and death. There is no specific antidote; symptomatic therapy, analgesics, and injections are prescribed.

Contraindications

The drug is not prescribed during pregnancy, breastfeeding, children and adolescents under 18 years of age. Other contraindications for the use of the drug Tiogamma are:

1. galactose intolerance;
2. hepatitis, cirrhosis;
3. epileptic seizures;
4. lactase deficiency;
5. glucose-galactose malabsorption;
6. hypersensitivity to the components of the composition or thioctic acid.

Terms of sale and storage

You can buy the drug Thiogamma with a prescription; it should be stored in a dry place, inaccessible to children, at a temperature of up to 25 degrees for no more than five years.

Analogues of Thiogamma

Thiogamma substitutes include those drugs that contain the same active substance. Analogues of the drug:

1. Lipoic acid is a tablet preparation, a direct analogue;
2. Berlition – tablets and concentrated solution based on thioctic acid;
3. Thiolepta - plates and solution for the treatment of diabetic, alcoholic neuropathy;
4. Thioctacid turbo is a metabolic drug based on alpha-lipoic acid.

The cost of purchasing Thiogamma will depend on the chosen form of release of the drug, the amount of medicine in the package and the pricing policy of the retailer and manufacturer. Approximate prices for the product in Moscow:

Solution for infusion 150 ml

Tablets 600 mg, 30 pcs.

Tablets 600 mg, 60 pcs.

Solution for infusion 50 ml, 10 bottles

Reviews

Alla, 37 years old The drug Tiogamma was recommended to me by a friend who lost weight on it beyond recognition. She took it with the doctor’s permission, after training, and additionally limited her diet. I started taking pills and eating right, and lost five kilograms in a month. Excellent result, I think I will repeat the course more than once.

Alexey, 42 years old Due to my addiction to alcohol, I developed polyneuropathy, my hands were shaking, and I began to suffer from frequent mood swings. Doctors said that we must first recover from alcoholism, and then eliminate the consequences. At the second stage of therapy, I began taking Thiogamma solution. It effectively copes with the problem of neuropathy, I began to sleep better.

Olga, 56 years old I suffer from diabetes, so I have a tendency to develop neuropathy. Doctors prescribed the drug Thiogamma for prevention, and additionally adjusted the insulin dose. I take the pills according to the instructions and see changes - I have become much calmer, I no longer have cramps at night and in the morning, my hands do not shake from anxiety.

Larisa, 33 years old I heard advice from a friend in cosmetology: use lipoic acid in ampoules to eliminate age spots and incipient wrinkles. I asked the doctor to write out a prescription and bought it and used it in the evenings: after washing my face, I applied the solution instead of tonic, and then the cream on top. Within a month, the spots began to disappear, the skin became noticeably fresher.

Prices in online pharmacies:

Thiogamma is a drug with antioxidant and metabolic effects; regulates carbohydrate and lipid metabolism.

Release form and composition

Thiogamma is available in the following forms:

1. film-coated tablets: biconvex, oblong, light yellow with white or yellow inclusions of varying intensity, there are marks on both sides; the cut shows a light yellow kernel (10 pieces in blisters, 3, 6 or 10 blisters in a cardboard pack);
2. solution for infusion: transparent, yellowish-green or light yellow liquid (50 ml in dark glass bottles, 1 or 10 bottles in a cardboard box);
3. concentrate for preparing a solution for infusion: transparent yellowish-green liquid (20 ml in dark glass ampoules, 5 ampoules in cardboard trays, 1, 2 or 4 trays in a cardboard pack).

1 tablet contains:

1. active ingredient: thioctic (alpha-lipoic) acid – 600 mg;
2. auxiliary components: microcrystalline cellulose, croscarmellose sodium, simethicone, colloidal silicon dioxide, lactose monohydrate, talc, magnesium stearate, hypromellose;
3. shell: talc, macrogol 6000, sodium lauryl sulfate, hypromellose.

1 ml of solution for infusion contains:

1. active ingredient: thioctic (alpha-lipoic) acid – 12 mg (per 1 bottle – 600 mg);
2. auxiliary components: macrogol 300, meglumine (to correct the pH value), water for injection.

1 ml of concentrate for the preparation of solution for infusion contains:

1. active ingredient: thioctic acid – 30 mg (per 1 ampoule – 600 mg);
2. auxiliary components: macrogol 300, meglumine (to correct the pH value), water for injection.

Indications for use

The drug Thiogamma is used to treat alcoholic and diabetic polyneuropathy.

Contraindications

1. children and adolescents up to 18 years of age;
2. pregnancy period;
3. breastfeeding period;
4. glucose-galactose malabsorption, lactase deficiency, hereditary galactose intolerance (for tablets);
5. hypersensitivity to the main or auxiliary ingredients of the drug.

Directions for use and dosage

Film-coated tablets

The drug Thiogamma in tablet form is taken orally, on an empty stomach, with a small amount of liquid.

Recommended dose – 1 pc. (600 mg) once a day. The duration of therapy depends on the severity of the disease and ranges from 30 to 60 days.

During the year, the course of treatment can be repeated 2-3 times.

Solution for infusion, concentrate for the preparation of solution for infusion

The drug Thiogamma in the form of a solution is administered intravenously slowly, at a rate of about 1.7 ml/min for 30 minutes.

The recommended daily dose is 600 mg (1 bottle of solution for infusion or 1 ampoule of concentrate for preparing an infusion solution). The drug is administered once a day for 2–4 weeks. After which the patient can be transferred to the oral form of Thiogamma in the same doses (600 mg per day).

The drug in the form of a solution for infusion is ready for use. After releasing the bottle from the box, it is immediately covered with a special light-protective case to prevent light from reaching the thioctic acid, which is sensitive to its effects. Intravenous infusion is performed directly from the bottle.

When using Thiogamma in the form of a concentrate, you must first prepare an infusion solution. To do this, the contents of one ampoule of concentrate are mixed with 50–250 ml of isotonic sodium chloride solution. The prepared solution is immediately covered with a light-protective case. The infusion solution is administered immediately after preparation. Its storage duration is no more than 6 hours.

Side effects

Film-coated tablets

1. digestive system: vomiting, nausea, diarrhea, abdominal pain;
2. central nervous system: change or disturbance of taste;
3. endocrine system: a decrease in the concentration of glucose in the blood and the resulting symptoms of hypoglycemia (headache, dizziness, visual disturbances, increased sweating);
4. allergic reactions: urticaria, itching, skin rash, systemic reactions (up to anaphylactic shock).

Solution for infusion

1. central nervous system: change or disturbance of taste, convulsions (up to epileptic seizures);
2. organ of vision: bifurcation of visible objects;
3. hematopoietic system: thrombocytopenia, thrombophlebitis, hemorrhagic rash, pinpoint hemorrhages in the skin and mucous membranes;
4. skin and subcutaneous tissue: eczema, itching, rash;
5. endocrine system: a decrease in the concentration of glucose in the blood and the resulting symptoms of hypoglycemia (headache, dizziness, visual disturbances, increased sweating);
6. allergic reactions: urticaria, systemic reactions in the form of nausea, itching and discomfort (up to anaphylactic shock);
7. reactions at the injection site: hyperemia, irritation or swelling;
8. other reactions: difficulty breathing and increased intracranial pressure (with rapid administration of the drug).

special instructions

In patients with diabetes, especially at the beginning of drug therapy, blood glucose levels should be monitored. If necessary, doses of oral hypoglycemic agents and insulin are adjusted.

If symptoms of hypoglycemia appear, Thiogamma should be discontinued immediately.

During the treatment period, it is necessary to refrain from drinking alcohol-containing drinks, since alcohol reduces the effectiveness of the drug and is a risk factor for the development and progression of neuropathy.

One 600 mg tablet contains less than 0.0041 XE (bread units).

Direct use of Thiogamma does not affect the patient’s ability to drive vehicles or operate other potentially dangerous mechanisms. But it is necessary to take into account possible side effects from the endocrine system, due to a decrease in blood glucose levels, such as visual disturbances and dizziness.

Drug interactions

When thioctic acid is used together with glucocorticosteroids, their anti-inflammatory effect is enhanced; with cisplatin – the effectiveness of cisplatin decreases; with insulin or oral hypoglycemic agents - their effect may be enhanced; with ethanol and its metabolites - the effectiveness of thioctic acid decreases.

Thiogamma binds metals, so the drug should not be used together with medications containing metals (for example, magnesium, iron, calcium). There should be an interval of at least 2 hours between taking thioctic acid and these drugs.

The solution for infusion should not be mixed with Ringer's solution, dextrose solution and solutions that react with SH groups and disulfide groups.

Terms and conditions of storage

Store in a dry place at a temperature not exceeding 25 °C. Keep away from children.

The shelf life of the drug is 5 years.

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