Vero-Epirubicin

Country of origin - Russia
Pharm-Group - Antitumor antibiotics

Manufacturers - Lance-Pharm (Russia)
International name - Epirubicin
Synonyms - Farmorubicin, Farmorubicin instant, Epilem, Epirubicin-Ebeve
Dosage forms - lyophilized powder for the preparation of intravenous solution 10 mg, lyophilized powder for the preparation of intravenous solution 50 mg
Composition - Active substance: Epirubicin.

Indications for use - Leukemia, non-Hodgkin's lymphoma, lymphogranulomatosis, multiple myeloma, ovarian, breast, stomach, liver, pancreas, sigmoid and rectal cancer, bladder (superficial), head and neck, bronchogenic lung cancer, soft tissue sarcoma, osteogenic sarcoma.

Contraindications - Hypersensitivity, history of therapy with cumulative doses of anthracycline antibiotics, severe myelosuppression, heart failure (including a history), pregnancy, breastfeeding.

Side effects - From the cardiovascular system and blood (hematopoiesis, hemostasis): heart failure (possibly developing several weeks after the end of treatment), toxic myocarditis, arrhythmia, arterial hypertension, bone marrow hypoplasia, leukopenia (is transient in nature, reaching a maximum level 10-14 days after the start of treatment; normalization of the number of leukocytes occurs by the 21st day), thrombocytopenia, anemia. From the gastrointestinal tract: gastrointestinal disorders (nausea, vomiting, diarrhea), anorexia, inflammation of the mucous membranes (stomatitis in the form of painful erosions, especially on the sides of the tongue and on the sublingual mucosa) - may develop 5-10 days after the start of treatment . From the skin: 60-90% of cases - alopecia (usually reversible), accompanied in men by the cessation of beard growth. Allergic reactions: rarely - fever, chills, urticaria, anaphylaxis. Other: asthenia, conjunctivitis, mucositis, hyperthermia, sclerosis of veins (with possible necrosis of surrounding tissues during extravasation), reddish color of urine (1-2 days after treatment).

Interaction - Pharmaceutically incompatible with heparin solution (precipitate formation is possible).

Overdose - Symptoms: increased side effects.

Special instructions - Restrictions on use: Childbearing age (if it is necessary to prescribe to patients of childbearing age, it is necessary to use reliable contraceptive measures), children's age (safety and effectiveness of use have not been established). Careful cardiac monitoring and monitoring of various laboratory parameters should be performed before starting therapy and regularly during treatment. Systematic monitoring of the cellular composition of the blood, the functions of the heart and liver, and the urate content in plasma is necessary. The total course dose should not exceed 1000 mg/sq.m., the recommended concentration is 2 mg/ml. Do not mix in the same syringe with other antitumor agents. In case of accidental contact with the skin, wash it thoroughly with plenty of water and soap; in case of contact with the eyes, wash it off with saline solution.

Literature - Encyclopedia of Medicines, 2004.