H2-Receptor Antagonist

An H2-receptor antagonist is a drug that blocks the action of histamine on H2 receptors. Histamine is a substance produced in the body that binds to H2 receptors in the stomach, stimulating the production of gastric acid.

H2 receptor antagonists reduce the production of gastric juice, reducing acidity in the stomach. It helps in treating conditions such as heartburn, gastric and duodenal ulcers.

H2 receptor antagonists include drugs such as famotidine, ranitidine and nizatidine. They belong to the group of antihistamines. H2 receptor antagonists are widely used in medical practice to treat diseases associated with high gastric acidity.

H2 receptor antagonists. Pharmacological properties.

Currently, 3 generations of H2 blockers and antagonists used in medical practice have been described (Appendix D). To choose a treatment method, it is necessary to assess the severity of the disease, contraindications and side effects. The effectiveness of any medications depends on the correct use and duration of their use, and not just on the drug prescribed for therapy.

The antiallergic effect is less pronounced compared to first generation antihistamines and, as a rule, is approximately 50%.

Drug interactions

Hydroxyzine may increase plasma levels of tricyclic antidepressants, such as nortriptyline, imipramine and desipramine, following a single dose administered with hydroxyzine. Under combined influence, an increase in their concentrations in plasma is observed with changes in the ECG.

Drugs that inhibit aminophylline metabolism: