Fatty Metamorphosis of the Liver

**Faty metamorphosis** - replacement of normal liver parenchyma with connective tissue with the formation of fatty lobules, caused by chronic alcohol intoxication, beta-additive effects of ethanol and the absence of its antagonists. Fatty liver metamorphosis (hepatocyte lipedosis) is accompanied by cytolysis and dysfunction of hepatic metabolism.

In the countries of Eastern and Western Europe, as well as in the United States, 45–65% of people in older age groups suffer from fatty metamorphosis. Hepatoprotectors that can prevent or minimize the negative consequences of fat metamorphism and portal hypertension have a critical role in the prevention of liver complications in people who consume moderate or excessive alcohol.

The human liver is larger in volume than all organs and tissues of the body, not counting the spleen (3500 cm³) throughout life - from 800 to 2200. For comparison, the brain weight is 1400–1500 g. This and some other structural features of the body determine its extreme sensitivity to any type of pathology: alcohol, viral, metabolic, endocrine, long-term drug load.

The main manifestation of fatty degeneration are large (more than 3 mm in diameter) areas of adipose tissue - lobules from light yellowish to brownish-brown. You