Hyperbilirubinemia Non-hemolytic With Kernicterus

Non-hemotic hyperbilirubinemia with kernicterus is a rare syndrome that can develop in newborns or young children. It is characterized by increased levels of bilirubin in the blood, which leads to a yellow coloration of the skin and mucous membranes.

Hyperbilirubinemia is a condition where the body cannot properly process bilirubin, which is a breakdown product of hemoglobin. Bilirubin is a pigment that is formed from the breakdown of red blood cells. When bilirubin is not eliminated from the body, it can accumulate in the blood and cause jaundice.

Non-hemolytic kernicterus is caused by the failure of the red blood cell nucleus to be destroyed by the HSP70 protein. This absence affects the formation of specific binding of the HPS70 protein to hemoglobin on the surface of the erythrocyte cell, and also prevents the binding of nuclear antigen on the surface of other blood cells.