Glomerulonephritis Hypocomplementary Persistent

Persistent hypocomplementary glomerulonephritis is a chronic inflammatory kidney disease characterized by a persistent decrease in the level of complement in the blood.

Main signs of the disease:

1. Proteinuria (protein in urine)
2. Hematuria (blood in urine)
3. Arterial hypertension
4. Edema

Reasons for development:

1. Immune system disorders
2. Infections (hepatitis C virus, HIV)
3. Taking certain medications

Diagnosis is based on urine, blood (low complement levels), and kidney biopsy.

Treatment: immunosuppressants, ACE inhibitors, diet with limited protein and salt. If ineffective - hemodialysis or kidney transplantation.

The prognosis depends on the rate of disease progression. With adequate therapy, long-term remission is possible.

Hypocompensated glomerulonephritis (Hypocomp) is a kidney disease based on an immune inflammatory process leading to the development of glomerulopathy (damage to the glomeruli).

In nephrological practice, protracted forms of primary and secondary Glomerulonephritis (GN), the symptoms of which do not decrease for six months or more, come to the fore. Therefore, the use of the term “chronic glomerulonephritis” (CGN) is much less justified than the previous one. Moreover, CGN occurs as an outcome of acute, as well as protracted or slowly progressive glomerulonephitis. And now we should talk about acute primary glomerulonephroptosis, and not about chronic glomerulosis (even prolonged), since there is also a persistent stage of development of the disease. Its division from more acute forms is a conditional concept, most likely in the nature of a “delay” phenomenon. In practice, not all patients are still recognized as having an oliguric stage in the development of the disease, even six months and a year after diagnosis, despite the presence of severe persistent creatinine syndrome (PCS) and progression of urinary disorders at the stage of partial compensation.