Paget's Disease

Paget's Disease

Paget's disease is a chronic bone disease that occurs primarily in older people. It affects the bones of the skull, spine, pelvis and long tubular bones. With this disease, the bones become thinner and their structure is disrupted. Sclerotic plaques appear on radiographs.

Paget's disease is often asymptomatic, but sometimes manifests itself with pain, bone deformation and increased fragility with fractures. The medical name of the disease is osteitis deformans.

In addition, there is a malignant tumor of the nipple of the breast, which is called Paget's disease. It resembles eczema in appearance and is accompanied by the infiltration of malignant cells into the breast tissue.

Also, a rare lesion of the vulva, manifested by the formation of specific epithelial plaques, is sometimes called Paget's disease. Such plaques histologically resemble nipple lesions in breast cancer. This lesion may be accompanied by tumors in other organs.

Paget's disease is a rare pathological condition of the human skeleton, characterized by the development and proliferation of osteoclastocytes - giant multinucleated histiocytes with atypical nuclear chromatin, consisting of brightly colored paraphilic nucleoli with a large amount of cytoplasm.

The disease is rare, occurs quietly and initially goes unnoticed. Paget's disease leads to increased bone fragility, changes in bone structure, and deformation. Often leads to complete loss of ability to work. A person begins to experience attacks of pain in the head, and his intracranial pressure increases sharply. If Paget's disease affects a brain organ, a variety of complications are possible. From a simple decrease in vision in one eye to encephalopathy. As the disease progresses, the patient loses the ability to self-care and becomes disabled. Without treatment, most people with Paget's disease die.

Paget's disease is a rare disease of the skeletal system, which is manifested by thinning of the bones, disruption of their structure, pain, a tendency to pathological fractures, often accompanied by various mental disorders. Pathological changes in bones develop mainly in older people. This disease affects the areas of the skull, spine, pelvis and long tubular bones. That is why its second name literally sounds like a disease of deforming osteodystrophic origin. Scientists believe that the occurrence of this disease is caused by magnesium deficiency in the human body. According to medical literature, pathology is found most often in men. This form of osteodystrophy manifests itself as symmetrical damage to the bones of the arms from the sternum and all the ribs. It is also quite rare that the disease is diagnosed with the development of pathological changes in the bones of the legs.

The disease carries a serious risk of developing breast cancer. There is still no consensus among gynecologists about the relationship between the two pathologies. Some doctors consider the form of oncology to be a secondary phenomenon, others argue that there is no cause-and-effect relationship between them. The causes of the disease are unknown. People over forty years of age are susceptible to the disease. It occurs equally often in both sexes. However, the pathology mainly affects people over seventy years of age who have had bone injuries, surgeries or infections. Women are most often affected by the disease. The fragility of the skull bones is an external manifestation of damage to pathological changes in hard tissues. The bones become loose and thinned. The bones show fracture lines, scars, or osteolytic lesions. Muscles become weak. **Bone denesis chondroostomy** is the most dangerous form of Paget's disease of bone degeneration. In this case, the upper part of the femur, ilium or ulna, ribs, and collarbone are affected.