Cholangitis Toxic

Introduction

Cholangitis is an inflammatory disease of the biliary tract that can be caused by various infections or toxins. One form of cholangitis is toxicological cholangitis, which occurs as a result of exposure to toxins in the human body. This article will discuss this form of cholangitis and its health consequences.

Definition of cholangitis toxicosis

Toxicological hepatitis is a liver disease caused by exposure to toxic agents on the organ, causing acute inflammation of the liver parenchyma with its necrosis. The basis of the disease is damage to cells with their subsequent death, as well as the formation of a regeneration node at the sites of cell death in the degenerative connective tissue stroma, the focus of which quickly and firmly acquires the properties of a focus of inflammation. In case of toxic hepatitis, it is very important to timely identify symptoms and hospitalization in a hospital to prescribe adequate treatment.

The toxogenic factor primarily affects the liver. The incubation period lasts from several days to several weeks. Then, against the background of reduced immunological protection, an infection of the biliary system occurs, aggravating the course of the disease. Bile clots form in the bladder and ducts, their dissemination, necrosis and suppuration of necrotic tissue (liver failure). The severity of the condition increases, intoxication increases up to the terminal stage, areas of necrosis appear in other organs and systems (brain, kidneys, intestines, etc.), blood clotting decreases, and severe hemorrhagic syndrome occurs. Lack of appetite, nausea, vomiting, abdominal pain, cough, high body temperature, myalgia and admyalgia are often noted. Complicated course - coma. If the patient refuses treatment, multiple organ failure, shock and death occur.

The most important condition for the effectiveness of anti-inflammatory therapy is the implementation of complex treatment using drugs with etiotropic effects. The prescription of detoxification and antioxidant drugs is a prerequisite, since with the development of the inflammatory process, endogenous intoxication occurs. In order to normalize the detoxification function of the liver, lactulose, carbolene, and octreotide are used. In more severe cases with clinical manifestations of cytolysis, it is recommended to administer sodium bicarbonate solutions, under the control of central hemodynamic parameters, with the prescription of antiemetics in combination, and when diagnosing hemorrhagic syndrome, vitamin K preparations. The basis for the treatment of hepatitis is antibiotic therapy, which helps prevent the breakthrough development of sepsis as a complication diseases.

At the first symptoms and the appearance of vomiting, the patient should be hospitalized in the intensive care unit for immediate intensive care. Before this, you can prescribe intramuscularly 0.25 g of chloramphenicol 4 times a day + 0.1 g of sulfonamides 3 times a day + 1 ml of corticosteroids 20-30 mg in the first three days and 40 mg for further 3 weeks. Prednisolone is recognized as the most effective. Improves the condition of rheopolyglucin infusion (5%