Little Multiple Erythematous Epithelioma

Little Multiple Erythematous Epithelioma is a rare skin disease that appears as multiple red spots on the skin. This disease is also known as erythema pigmentosa multiplex or lichen planus multiplex.

Little erythematous multiplex epithelioma usually occurs in young people, especially women. It can be caused by a variety of factors, including stress, hormonal changes, infections and other diseases.

Symptoms of little erythematous epithelioma multiplex include multiple red patches on the skin that may be itchy or painful. They can appear on any part of the body, but most often affect the face, arms and legs.

Treatment for little erythematous epithelioma multiplex may include the use of topical corticosteroid creams and ointments, as well as antihistamines. In some cases, the use of systemic corticosteroids may be required.

The prognosis of little erythematous epithelioma multiplex depends on the severity of the disease and its duration. This condition usually goes away on its own after a few months or years. However, if symptoms persist or worsen, you should contact your doctor for further evaluation and treatment.

Little Multiple Erythematous Epithelioma: diagnosis requiring clarification

LittleM. - Italian dermatologist who described in the 19th century the manifestation of multiple erythema - a skin lesion that includes a rash, usually localized erythema and foci of leukoplakia.

Variations of the name include an abbreviation like e.g.g. when referring to translation to and from English. According to some researchers, his symptom definition should be considered as an attempt to find corticosteroid therapy to treat other autoimmune diseases. The skin diseases that Little M. and his student Moran defined in 1873 as "typical chronic erythemas" consist of a mild form of granulomatous rash or plaques (with external scaly features) associated with itching or painful symptoms that resolve spontaneously by the end of the first year in adults, possibly with minimal or no therapy. In contrast, he defined severe chronic erythemas as nodular lesions or affected areas without skin manifestations requiring active treatment. Those are already known to be clinically limited today with a typical positive reaction to antidepressants such as trazodone (TLD) and vivadate (trazadone).

One of Little M's major works is the book Therapeutic Problems, in which he was one of the first to suggest that cancer may have a long presymptomatic clinical phase, followed by rapid internal spread of the malignant neoplasm. This means that there are rare treatments that can be successfully used in this "golden phase", provided that the correct diagnostic methods can guide certain treatment approaches.

According to Little's hypothesis, hypodermic carcinoma can be defined as the only histological diagnosis of the skin that produces a positive TLD-T, with the presence of fragile lysis of blood biomolecules syndrome. It is believed that this symptom may indicate the presence of a subtle factor that encourages some malignant cells to become the site of initial spread. He proposed this approach as a therapy for vivadate-sensitive malignancies, as patients with refractory tumor progression sometimes achieve long-term remission after a series of intravenous TLD infusions.

Recent studies have also supported his hypothesis, suggesting that the skin changes he first described as erythemal epidermotrophic changes (EED) or weak blood and clear palate syndrome (DNSS) are associated with the development of certain carcinogens and