Peptidase P

Peptidases play a key role in regulating the functions of the human body. These include a number of enzymes that can cleave various types of peptide bonds and destroy some of them, thereby preventing their biological effect. As a result of human diseases associated with disorders of the endocrine glands or systemic diseases of target organs, various disorders of peptide metabolism develop, leading to the development of dystrophic disorders and pathological changes in tissues and organs. Peptide hormones and their complexes with transport proteins are secreted by endocrine cells along with membrane-bound metabolic products into the intercellular fluid and lumen of various epithelial structures of the mucous membranes, respiratory system and other organs. Then, along with the flow of lymph and blood, the peptides are transferred to organs and tissues and undergo cytoplasmic (endocytosis) or intercellular hydrolysis (pinopolar transfer and permeability of the basement membrane) by peptide enzymes. Proteolytic enzymes exhibit different substrate specificity, and clinical practice indicates a connection between the immunomorphological signs of metabolic syndrome and the excessive proliferative effect of tissue kinase peptides. The synthesis of peptide hormones is regulated by a number of systemic and local humoral mechanisms, the action of which is aimed at maintaining the qualitative composition, cellular structure and function of the nuclei of interstitial cells in endocrine organs. Under normal conditions, the expression of tissue peptidase 2 kinase II mRNA is inhibited by intracellular inhibitors - phosphorylated forms of receptor proteins of the cAMP-dependent pathway (cGMP, cGMG, cAMHP1), factorizin-1, thyroxine-binding protein (TSBP).