Shinkarenko-Mokhova Proba

Shinkarenko Mokhova sample

The Shinkarenko-Mokhov test is a method for determining the toxicity of drugs, which was developed by Soviet toxicologists I. P. Shinarenko and L. A. Mokhov. This method is used to evaluate the toxicity of drugs that can cause various side effects in patients.

The method is based on measuring the level of toxins in the patient's blood after taking the drug. If the level of toxins exceeds a certain threshold, this means that the drug is toxic and may cause side effects.

To carry out the test, the patient takes the drug, after which, after a certain time, his blood is taken for analysis. The analysis is carried out using special methods such as chromatography or spectrophotometry.

The Shinkarenko-Mokhova test is one of the most accurate methods for determining drug toxicity. It allows you to quickly and accurately assess the toxicity of the drug and take measures to prevent side effects.

Human red blood cells are susceptible to genetic vulnerability when exposed to a number of chemical compounds. A hereditary defect in this metabolism is known as galactosemia. If there is a lack of enzymes involved in the metabolism of galactose, an excess of its metabolite, galactose-6-phosphate, or a deficiency (accumulation) of galactooligosaccharides accumulates in the human body.

However, if you look at the biochemical patterns of pathological processes, you will notice another pattern: the levels of these metabolites are not constant values, they are dynamic values, changing depending on changes in the concentrations of substrates in the blood. That is, an increase in the concentration of the substrate leads to a change in the concentration of metabolites. An increase in the concentration of substances per unit volume of body cells is called hypermetabolism, and a decrease is called hypometabolism. Consequently, in different parts of the genome, gene copies that should regulate metabolic processes among themselves can be formed with different functional and dynamic activities. A change in the functions of the metabolite generation system (along with the intensity of the breakdown of the substrate itself) is one of the key factors in the development of pathology. Indeed, normalization of extra-systemic regulatory coefficients - binding constants and catalytic constants, eliminates all changes in metabolic processes and, as a result, normalizes the process or mechanism where the disorders occurred (functions, regulatory centers, cells).

In order to diagnose various forms of hereditary diseases associated with impaired exchange of glycosyl bases in cell membranes, a number of biochemical tests are carried out, including determining the relative intensity of reactions with substrates. One of the most sensitive tests is normally considered to be the determination of the HTC membrane