Langendorff cells

Langerhans cells or Landendorff cells are cells of the immune system of humans and other mammals.

It is a large flattened macrophage with one or more nuclei. They are located in the connective tissue of organs, body cavities (mainly in the lungs, bone marrow), paraganglia of the visceral nerve ganglion, and the central nervous system. They are characteristic of invertebrate animals, but Langerhan cells are also found in multicellular higher algae. The shape and size allow Langerkan cells to fit tightly into the vasculature and regulate blood flow, thus protecting internal organs from external factors.

Since they are macrophages, an important aspect of their function is the disposal of everything unnecessary and foreign: bacteria, viruses, blood cells, tissue fragments, including dead own cells. To destroy foreign objects, macrophages secrete toxins such as lactoferrin, cationic granule protein (bosentanoyl-transporin) and cytotoxic peptides. In the process of decomposition of macrophage remains, plasma cells also participate, secreting serum proteases and destroying the decaying remains of Langercan cells due to the action of serine proteases, such as aspartate proteinase and glutamate-aspatamyopeptidase.

Langerax cells also produce immune cytokines that