Steatocystomatosis

Steatocystomatosis (steatocystomatosis; steato- + Greek kystis bladder + -oma + -oz; synonym: pilosebocystomatosis, Pringle steatocystoma multiple, sebocystomatosis, steatocystoma multiple) is a rare hereditary disease characterized by multiple cystic formations in the skin, sebaceous and sweat glands.

The disease is caused by a mutation in the CYLD1 gene, which encodes a tumor suppressor protein. The mutation leads to disruption of the regulation of the cell cycle and proliferation of skin cells and its appendages.

Clinically manifested by the appearance of multiple dense nodes in the skin, often on the face, trunk and limbs. The nodes slowly increase in size, have a dense elastic consistency, and are painless.

Diagnosis is based on the clinical picture and histological examination of a skin biopsy.

Surgical treatment is excision of individual nodes. The prognosis is favorable.

steatocystasis

Steatocystamosis is a rare disease characterized by the appearance of multiple small, flat and slightly asymmetrical lesions in the perimenopausal period. They can also occur in middle-aged men and women. The initial symptoms of steatecytosis appear on the skin of the sternum and scalp. This disease develops after excessive intake of fatty foods, alcohol consumption or other factors that can cause changes in a person's metabolism. In most cases, these new cells are similar to normal fat cells in the skin, but differ in structure and biological properties. The syndrome is difficult to treat with hormonal and other medications. In very rare cases, steatocystomosis can lead to skin cancer. Diagnosis is necessary to exclude other diseases such as acne and seborrhea. However, therapy is completely symptomatic. The use of antibiotics should be limited as they can increase sebum production.