Cystothionine-G-Lyase

Cystothionine-γ-lyase (CGL) are enzymes that participate in the metabolism of cysteine, one of the most important amino acids in the human body. They catalyze the hydrolysis of cysteine ​​to cystidine and sulfur(IV) oxide, which can then be used to synthesize glutathione, an important antioxidant in the body.

Cystothionine g-lyases play an important role in maintaining body homeostasis, as they participate in the synthesis of glutathione, which protects cells from oxidative stress. In addition, cystothionine G-Lyases are also involved in the regulation of blood pressure and kidney function.

Cystothionine G-lyase enzymes were first discovered in the 1950s when researchers discovered that cysteine ​​could be used as a substrate for enzymatic hydrolysis. Since then, more than 20 different isoforms of cystothionine G-lyases have been discovered, which have different functions and are localized in different tissues and organs.

Currently, cystothionine G-lyase is the subject of active research due to its role in the treatment of various diseases, such as sickle cell anemia, cardiovascular diseases, diabetes, etc.

Cystinothionine G-Lyase (CTGL) is an enzyme that plays an important role in maintaining body homeostasis by regulating the levels of cystine and methionine, two essential amino acids. This enzyme is located on the membrane and pumps amino acids into the extracellular fluid and back into the cells. There are three main types of CTGL in this process, type A, B and C, each of which functions differently and plays a specific role in the metabolism of these amino acids. CTGL is also found in several other animals, including single-celled organisms and ciliates. An interesting fact is that some Aspergillus species and bacteria can produce and secrete CTGL into the environment, allowing mold to form the "white arcs" commonly seen when food is dried outdoors.