Erythroblast Primary

Erythroblastic conversion in mammals occurs in various organs, but most of it occurs in the bone marrow, where about 50% of erythropoiesis precursors are converted into erythroblasts in the first week. The remaining stages of erythroid cell development occur in the liver, spleen, lymph nodes and other organs and tissues. The rate of cell development, the stage of cell development, its ability to reproduce, and, accordingly, the rate of red blood cell production, largely depend on the oxygen status of the body. Excess oxygen inhibits the transition of cells to the stage of globin synthesis, preventing erythroblasts from reaching the final point of transformation - the megaloblast - and a mature erythrocyte with a respiratory surface sufficient for normal functioning. That is, the transformation of erythronormoblasts into megaloblasts is regulated by changing the factors of incoming oxygen in order to create the most efficient transport system for the transfer of gases. It is obvious that erythroplasmic transformations take place under the control of a system of complex regulators throughout the myeloid stage of hematopoiesis, when young “acute-phase” cells are formed only from the precursors of myelopoiesis and continue to divide only until a certain stage of development, after which they irreversibly transform into other hematopoietic cells. The generally accepted opinion that the so-called acute phase reactions are not related to diseases in general, but are a normal protective reaction of the body, needs clarification. K. Selmez notes that during any disease an inflammatory reaction of cells can occur. The functions of the receptors are nonspecific for the pathogen, but there is a difference in the structure of the membranes of neutrophils and lymphocytes with a sufficient number of surface receptors. There is no recognition function to detect germs. The reaction to a microbial molecule is not determined by anatomical