Hyperbilirubinemia of Newborns Transient Familial

Transient familial hyperbilirubinemia of newborns (hyperbilirubinaemia neonatorum transitoria familiaris) is a condition characterized by increased levels of bilirubin in the blood of newborns. It is temporary and often occurs in some families.

Reasons for development:

1. Hereditary defects in enzymes involved in bilirubin metabolism
2. Reduced activity of glucuronyl transferase, the enzyme responsible for the conjugation of bilirubin in the liver
3. Increased hemolysis of red blood cells in a newborn

Clinical manifestations:

1. Yellowness of the skin and sclera
2. Increased levels of indirect bilirubin in the blood
3. No signs of liver damage

Diagnosis is based on determining the level of bilirubin and its fractions in the blood, excluding other causes of jaundice.

Treatment includes phototherapy. The prognosis is favorable - after 2-3 weeks of life, the bilirubin level returns to normal. Hyperbilirubinemia does not recur in subsequent pregnancies.

Newborn babies may be susceptible to high levels of bilirubin in the blood. Bilirubin is a breakdown product of hemoglobin, which is found in red blood cells. Normally, it is excreted from the human body using the kidneys and liver. However, if bilirubin levels increase, it can cause serious health problems for the newborn.

Neonatal hyperbilirubinemia is a condition in which babies have elevated levels of bilirubin, which is life-threatening. The cause of hyperbilirubinemia may be poor functioning of the liver and other organs, as well as genetic abnormalities.

One of the types of hyperbilirubinemia is neonatal transient hyperbilirubinemia - a variant in which the appearance of high levels of bilirubin in newborns appears in the first days of life, 6-13 days after birth, and by the 3rd month of life the level of bilirubin returns to normal.