Minkowski-Choffard Disease

Minkowski-Choffard disease is a rare disease of the pancreas characterized by a combination of diabetes mellitus and pancreatic acidemia.

The disease is named after the two doctors who described it - Oscar Minkowski and Albert Chauffard.

Main symptoms include:

1. Diabetes mellitus due to insulin deficiency
2. Steatorrhea and fat malabsorption due to deficiency of pancreatic lipases
3. Malabsorption of proteins, carbohydrates and fats due to pancreatic insufficiency
4. Weight loss and exhaustion

Diagnosis is based on blood tests (hyperglycemia, decreased bicarbonate), stool analysis (steatorrhea), and imaging of the pancreas (atrophy, calcifications).

Treatment includes insulin therapy, enzyme preparations, and a fat-restricted diet. The prognosis with adequate treatment is favorable.

Acute lymphoblastic leukemia (ALL or Shoffard-Minkowski disease) is a malignant disease of hematopoietic tissue, accompanied by metastasis in the osteoarticular and lymphatic systems. The main cause of the disease is damage to the chromosomal apparatus, which is often a consequence of DNA mutations in the precursor cells of the myeloid series - blast cells. As a result of this process, the production of normal blood elements stops, and their place begins to be taken by waste products of malicious BLs, which include all leukocytes. Among the most common forms of tumors of the circulatory system are blast cells. Some of them enter the metastatic process, weakening the immune system and causing many other problems with internal organs. Another of the most common causes of leukemia in a child is blood transfusion. There are other causes of ALL, but even with such a “favorable” situation, there is practically no chance of recovery. The disease develops rapidly and can pose a threat to the life of a small patient. Rarely detected on time due to suboptimal localization of malignant elements. Oncology therapy is complicated by