Hyalinosis of the Skin and Mucous Membrane

Hyalinosis of the Skin and Mucous Membrane: Causes, Symptoms and Treatment

Hyalinosis of the skin and mucous membranes, also known as lipoidosis of the skin and mucous membranes, lipid proteinosis, Urbach's extracellular cholesterosis or Urbach's, is a rare genetic disease that leads to the accumulation of glycoproteins in various tissues of the body.

The causes of hyalinosis of the skin and mucous membranes are associated with impaired lipid metabolism in the body. This leads to the accumulation of hyaline-containing glycoproteins in various tissues, including the skin, mucous membranes, lungs, kidneys and heart. Hyaline is a substance that is normally released by the body to fight infections and inflammation.

Symptoms of hyalinosis of the skin and mucous membranes may include yellowing of the skin, thickening of the skin and mucous membranes, enlargement of the liver and spleen, breathing problems and heart problems. These symptoms may appear in newborns or early childhood.

Diagnosis of hyalinosis of the skin and mucous membranes may include a biopsy of the skin or other affected tissue, as well as genetic tests. Treatment is aimed at reducing symptoms and may include oxygen therapy, organ transplantation, and symptomatic therapy.

In conclusion, hyalinosis of the skin and mucous membranes is a rare genetic disease that leads to the accumulation of glycoproteins in various tissues of the body. Symptoms may include yellowing of the skin, thickening of the skin and mucous membranes, and breathing and heart problems. Diagnosis may include a skin biopsy or genetic tests. Treatment is aimed at reducing symptoms and may include oxygen therapy, organ transplantation, and symptomatic therapy. If you suspect hyalinosis of the skin and mucous membranes, you should consult a doctor for diagnosis and treatment.

Hyalinoses are a group of genetically heterogeneous, degenerative-dystrophic diseases of the skin and mucous membranes, in which cells of different origins and different morphologies are found in the dermis and epithelium, containing very large and refractory eosinophilic amorphous intracellular or intercellular inclusions (“balls”) of many nucleoproteins and their fragments ( 60-80%). The presence of mitoses is also characteristic. The histological structure of the dermis is dominated by fibroblasts of various types and neoplastic blasts.