Calciphylaxis

Calciphylaxis is a pathological condition characterized by a disorder of calcium metabolism in the human body. As a result, calcium accumulates in tissues and organs, which can lead to serious complications.

Calciflaxia can be caused by various reasons, such as hereditary diseases associated with calcium metabolism disorders, excess calcium intake from food, as well as taking certain medications.

One of the most common symptoms of calciphylaxis is bone and joint pain. Problems with teeth, nails and hair may also occur. In addition, there may be a decrease in muscle strength, memory loss and concentration.

To treat calciphylaxis, it is necessary to diagnose and determine the cause of its occurrence. After this, appropriate treatment is prescribed, which may include lifestyle changes, medications and surgical interventions.

It is important to remember that calciphylaxis is a serious disease that can lead to irreversible consequences. Therefore, if symptoms appear, you should consult a doctor for diagnosis and treatment.

Calciphylaxis – new bone formation

Calciphylaxis (calciphoria, pseudocalcification, from the Latin calcinum “limestone”) is a very rare disease of mineral-bone metabolism, which is based on excessive calcification of the interstitial and supranoperiosteal spaces and bone metaphyses. Calcification occurs not only as a result of hypercalcemia, but also with hypomagnesemia and hypophosphatemia. In tissues there is an increase in the content of inorganic calcium (hypercalcemia), mainly due to the ionized element.

There is a distinction between primary chronic calcification, which is an independent pathology, a hereditary anomaly, and a secondary chronic process, which forms in pathological conditions and skeletal diseases. Among the latter, the following forms of the disease are distinguished:

1. hyperparathyroid (thyrotoxicosis, adenoma, hyperplasia of the parathyroid glands). Thyrotoxicosis leads to an increase in calcitonin levels. Diffuse hyperparathyroidism develops, which is characterized by a sharp increase in the formation of parathyroid hormone (PTH). The mechanism of action of PTH at elevated levels of the hormone is due to an increase in the permeability of ion channels, which leads to the transition of calcium from the intracellular space into the blood; 2. steroid with hypercalcemia of various etiologies. The steroid form of the generalized process is a medicinal form of secondary active hypercalcemic tetany, which usually develops in patients with toxic goiter. The disease is characterized by a slight increase in the level of leukocytes. Distinct changes in the proteolysis profile were noted. A fairly high level of parathyroid hormone was detected. It is known that parathormone, a protein compound contained in the human body, affects various processes of bone metabolism and activates the absorption of calcium by the intestine; 3. various rickets diseases. Primary rickets is a disease of childhood that occurs as a result of an early violation of bone formation with genetic and postnatal defects in the function of the resorption system, arising for various reasons (infectious diseases, malnutrition, lack of physical activity); 4