Kimmelstiel-Wilson Syndrome

**Kimmelstiel-Wilson** syndrome is a genetically heterogeneous group of diseases caused by mutations of genes localized primarily on chromosome 1q32-3q41, encoding calcium-binding proteins that provide a mechanism for basal resorption of bone tissue from the growth zones of young bones of the trunk and extremities of patients. The clinical manifestations of these syndromes range from microstomy, osteomalacia and neurological manifestations to anemia, sickle cell hemolytic anemia and Marfan syndrome with pituitary dwarfism. Like

One of the most interesting medical syndromes is Kimmell-Wilkinson syndrome, also known as slow glomerular filtration disorder or non-neonatal adult kidney disease. The syndrome occurs in older people suffering from kidney diseases such as hypertension.

P. Kimmelstiel and Alfred S. Wilson were American doctors who independently described the disease in their scientific papers. Kimmillil described this disease in an elderly patient suffering from hypertension and chronic glomerulonephritis. He found that this patient's renal glomeruli were significantly reduced in size, which led to impaired urine filtration. The patient suffered from severe hypertension and was hospitalized. After several weeks of treatment, his condition improved and he began to recover. However, he died of heart failure a few months later.