Wilms tumor

Wilms tumor is a rare kidney cancer in children and adolescents. It is characterized by rapid growth, an aggressive course and has a tendency to metastasize to other organs.

Unfortunately, medicine still cannot name a clear cause for the appearance of Wilms tumor. This is usually a hereditary disease. There are suggestions that the risk of developing Wilms tumor increases in people whose parents had a hereditary predisposition to cancer. Research also suggests the influence of harmful chemicals in the air, such as asbestos, benzopyrene and perchlorethylene, which may contribute to the formation of adenomas and can be transmitted

Wilm's - or nephroblastoma - is a malignant tumor of the kidney. In 1927, a doctor of Polish origin, Norman Wilms, noticed it in his child, for which he received such an unusual name. Before the discovery of the structure of genetic mutations, this type of cancer was considered one of the rarest. It was most often diagnosed in women and was most common in childhood. More than one hundred thousand cases of cancer are diagnosed in the world every year, and the effectiveness of therapy is no more than 50%.

Infection is detected during routine testing. The development of the disease depends on the degree of neglect of the tumor process. A number of symptoms indicate metastases:

- Pain in the back, side with irradiation down the abdomen on one or the other side; - Fat deposits on the anterior abdominal wall, abdominal cavity; - Sudden loss of body weight; - Increased sweating; - Hyperthermia without an objective reason.

A thorough history taking, detection of malignant tumors in close relatives, the presence of diseases of the ovaries and uterus, and treatment of infertility with estrogen drugs increases the risk of developing cancer.

Adenocarcinoma occurs

Wilms tumor is a rare malignancy that is the most common type of kidney germ cell tumor in children and young adults under 20 years of age. This tumor is called adenomyosarcoma and is a combination of epithelial tissue and connective tissue, giving it a slightly different shape and appearance compared to other types of tumors.

Wilms tumors arise from cells in a child's genitourinary tract and usually develop in the right kidney, but can also affect the left kidney or both kidneys. The swelling may initially be detected as a lump or dull ache in the upper abdomen, but may present with more serious symptoms such as vomiting, lower back pain, fever, weakness and fatigue. These symptoms may vary depending on the size and severity of the tumor.

Diagnosing Wilms tumor is quite difficult, as it often resembles other tumors such as benign neoplasms or renal cell carcinoma. Therefore, a CT scan, magnetic resonance imaging, or even a biopsy is often required to confirm the diagnosis. Depending on the patient's severity and the extent of kidney damage, surgery, chemotherapy, radiation, or a combination of these treatments may be required. In addition, most patients, after successful treatment, undergo observation and treatment under the supervision of a physician.

The most common symptoms of a Wilms kidney tumor include pain, malaise, fatigue, loss

Wilms tumor is a rare malignant neoplasm that arises from the nephron epithelium in the renal medulla. Most often, the tumor has a large-format appearance in the upper segment of the kidney and is characterized by an aggressive course. It belongs to the Sternberg-Troyanow tumor family, also known as Wilms tumor, neuroendocrine tumor, or fibromuscular tumor. This article discusses the main aspects associated with this disease and its treatment.

Wilms tumor is the most common form of childhood cancer in children under 15 years of age. It was first described in 1892 by the German physician Wilhelm Wilms, the son of the outstanding pathologist Karl Friedrich Wilhelm von Wilms. The tumor originates from mesenchymal cells and often develops in both kidneys. However, the diagnosis is sometimes made by chance, when an oncological process is detected in one of the kidneys. It occurs more often in boys and usually appears between the ages of 2 and 7 years, but can also develop in adolescents.

The disease is often asymptomatic. There may be nonspecific complaints of flank pain, bleeding from the urinary tract and progressive weakness. If the tumor arose in the left kidney, then due to its location, the outflow of urine may be disrupted. This can lead to painful frequent urination, nighttime urination, hemorrhagic cystitis, bladder enlargement and other severe symptoms. Early symptoms include pain in the lower back or abdomen, fatigue, increased sweating, constipation, poor appetite, weight loss and lack of improvement after courses of antibiotics. May also be observed