Acidosis Subcompensated

In the body of any living creature, metabolites of varying degrees of oxidation are formed, each of which is in a state of dynamic equilibrium and reflects the expediency of exiting it into the body with blood or further with urine. If the formation of metabolites is stronger than their neutralization, blood acidification occurs, which leads to acidosis. At the same time, the ratio of compounds that determine the acid-base balance of the body (ABC) changes.

There are several types of acidosis: compensated, subcompensated and decompensated. Acidosis is the result of increased distal tubular transport of protons, caused by increased synthesis of ketone bodies due to increased concentrations of substrates such as amino acids, fat, carbohydrates, and decreased reabsorption of ammonia in the distal renal tubules. There is also a decrease in the excretion of ammonium ions, phosphates, sulfates and chlorides (due to osmotic depression), as the balance of the tubular-proximal ducts is disturbed. Reabsorption is also reduced for creatinine. The blood becomes more acidic, pH less than 7.2 (urine pH 4.5 - 6.9). If such acidosis persists for more than two weeks, it most often turns into a decompensated form. The latter can only be compensated by intravenous infusion of alkaline solutions. With decompensation, the blood pH level drops below 7.

The subcompensated form is characterized by the persistence of effective alkalosis, and the pH level is maintained at 7 or higher, regardless of specific