Amyloidosis Perireticular

Perireticular amyloidosis (a. perireticularis; synonym a. parenchymal) is a type of amyloidosis in which amyloid deposits are localized mainly around the vessels and in the perivascular spaces of various organs.

Most often the kidneys are affected, less often the spleen, liver, lymph nodes and other organs. In the kidneys, amyloid is deposited around the glomerular capillaries and in the walls of small arteries and arterioles. This leads to disruption of the blood supply to the glomeruli and the development of their hyalinosis.

Clinically, perireticular amyloidosis is manifested by proteinuria, hematuria, arterial hypertension, and gradual impairment of renal function. The diagnosis is confirmed histologically by identifying typical perivascular amyloid deposits in a biopsy specimen of the affected organ.

Treatment is usually symptomatic. The prognosis is serious due to the progressive nature of the disease and the development of chronic renal failure.

Amyloidosis is a disease characterized by the deposition in tissues of a characteristic protein-polysaccharide complex of amyloid, consisting predominantly of fibrillar proteins and their breakdown products. Amyloid deposition is the result of a violation of the metabolism of complex proteins in the body, while the content of endogenous biogenic amines and metabolic cofactors deviates from the norm, which entails a more active production of amyloid polypeptides, which in turn lose the ability to be absorbed and excreted from the body.

Thus, the physiological mechanisms of normal metabolism of protein and polysaccharide components in the liver are disrupted under the influence of various negative environmental factors, such as genetic predisposition, exposure to toxic toxic substances, excess or deficiency of microelements, unhealthy diet and much more, which affects the functioning of metabolic processes in organism.

Some risk factors may affect men much less than women, so age differences in the likelihood of developing this disease are small. Pregnancy and menopause are periods in a person’s life during which significant changes occur in the biochemical composition of the female body. As a result of these changes, in women over 45 years of age the risk of developing the disease is significantly higher, while in young girls this factor has a rather low percentage of development. It is also known that some hepatotoxic antitumor drugs such as Interferon, Melphalan, cyclophosphamide can provoke the spontaneous occurrence of amyloidosis.

If you regularly visit a doctor with complaints regarding the symptoms of a disease, the problem can be treated by several specializations of doctors, for example, therapists, narcologists, oncologists or infectious disease specialists. The direction of treatment largely depends on how far the disease has progressed in its development. In case of amyloid deposits in tissues that are limited in area, conservative treatment can be used, and in case of extensive damage to multiple organs, surgical correction of the condition is indicated. With timely detection and adequate treatment, the chances of recovery are quite high, but in the case of an advanced amyloidosis period, even after a successful operation, survival statistics leave much to be desired.