Amyloidosis Tumorous

Amyloidoses are a group of diverse heterogeneous hereditary or acquired diseases caused by impaired protein synthesis or metabolism. It has long been believed that amyloids are proteins or fats and glycogens, but later they became convinced that amloid-like fibrils are of a protein nature, consisting of small molecules (glycoproteins), which are deposited in tissues during disease. Amyloids are especially visible in histological sections with Congo violet dye.

Pathomorphology of amyloid tumors 125. An amyloid (amyloid) tumor is usually a soft, globular neoplasm of dense consistency, the size of a chicken egg or slightly larger, pale yellow in color or sometimes grayish-white. The vessels are few. When cut they look uniform. Bubbles of argyrophilic granularity are single. The edges of the tumor are sharply outlined. Microscopically, an amyloid tumor consists of many cross-striated amloid phyloids with a diameter of 6-10 microns, which are crowded and very close to each other. They often contain pale-colored trampus, Rubin bodies and, less commonly, red blood inclusions. Gradually, amyloid filaments are transformed into irregularly crumb-shaped deposits due to the movement of the filament mass in the proximal direction of the tumor mass. The formation of polygonal grains with a characteristic spherical arrangement is possible. Sarcomatous nodules are sometimes found. Cell anaplasia and sarcomyeloid features are absent. The central area is filled with fibrous tissue. Sometimes in the second zone there is hyaline cell degeneration. A positive response is determined immunohistochemically using the Blackstein fluid + gold tetrathiacetate reagent. Electrophoresis identifies multiple spectra, which in a healthy person are characterized by multiple small amplitudes. No specific mutations of proteins are detected in the media, and no disturbances in the structure are visible. Toxidermia, inflammatory reaction Usually the cause is contact of the skin or mucous membrane with the amyloid substance, less often - the spread of a foreign body, sometimes through the circulatory system.