Bremer Syndrome

Bremer syndrome is a rare disease that is diagnosed in people aged 47–60 years. According to scientists, the disease is transmitted genetically, but there is no confirmation of this fact yet.

The disease was named after the neuropathologist Bremer, who discovered it in Germany in the 19th century, then

Bremer syndrome is a rare but severe neuropsychiatric disease, which is characterized by acute personality degradation in the form of mental abnormalities, leading to a sharp decline in cognitive functions and disability of the patient.

The exact cause of Bremer syndrome is unknown, but modern science identifies several factors that can trigger it. Such factors include infections, intoxications, status epilepticus, diffuse organic brain damage, as well as liver and metabolic disorders. In some cases, exposure of the brain to radiation, chemicals or toxic substances can also contribute to the development of Bremer syndrome.

Bremer syndrome (Bremer syndrome) – Fibrillary glomerulonephritis. Symptomatic fibrillary glomerulopathy). BS is one of the types of fibrillary glomerulopathy (fibrinoid necrosis of small vessels of the glomeruli of the kidney, causing renal failure and proteinuria). BS was first described in 1950 by Rollend Bremer, a Swiss dermatologist who studied the microscopic features of skin areas affected by artillery shell explosions. This type of necrotizing vasculitis is named after him. The disease manifests itself mainly as skin manifestations, ending in the development of chronic renal failure.

The syndrome is named after the German dermatologist and radiologist Friedrich Wilhelm von Breymer (Friedrich Wilhelm Heinrich Ulrich Freiherr von Breymann, March 14, 1883 - September 22, 1974), who named this type of necrotizing arteritis of the skin. Under an electron microscope, a typical picture for this disease is visible - fibrils - flat and thin protein filaments, strongly protruding

Bremer syndrome ("pseudoconvulsive", "pseudogeneralized" or "bubbling paraphasia syndrome") is a rare neurological disorder that is characterized by confused thinking, loss of control of language and stiffness of movement. It was first described in 1907 by John Bremer, but its importance was only reassessed many decades later.

Bremer's syndrome is characterized by incomplete bubbling, smacking, and voluntary contractions of the muscles of the pharynx and larynx. At one time it was believed that this disease was senile (late delirium or Parkinson's disease). It is now believed that this is a chronic inflammatory process in the brain, apparently arising from magnesium deficiency (an m-cholinergic component important for the transmission of nerve impulses). From the point of view of modern neurophysiology, it may be associated with an insufficient effect of serotonin on the structures of the central nervous system in older people. The disease progresses slowly and is accompanied by quite complex disturbances in thinking, speech and movement. Phonemes (sounds), words and phrases sound unique. Thinking becomes unclear and illogical, and patients have difficulty writing words and performing complex tasks. Manifestations of Bremer syndrome are varied, ranging from completely minor problems in thinking and voice to an almost complete loss of control over the body and the ability to communicate adequately. Bremers often experience anxiety, nervousness, and emotional instability. One of the main signs of the disease is incomplete gurgling and spasms of the larynx, which can progress and intensify when talking, reading or writing. Language may also become too fast, slurred, and labored. Although Bremer syndrome is a fairly rare disorder, many people experience it. Symptoms usually appear over the age of 50, although in rare cases they can occur in younger people. Among the most common symptoms, doctors note phonetic slurred speech, rapid and unnatural speech, and involuntary gurgling noises during conversations.