Giant Cell Transformation of the Neonatal Liver

Giant cell liver disease (GVH) is a rare disease of newborns that occurs when a viral or bacterial agent invades the liver. It is characterized by a large number of large cells (giants) in the newborn's liver, which appears enlarged due to abnormal cell growth. This is a rare but potentially dangerous disease that can cause serious consequences for newborns and their mothers. In this article, we will look at what GVH is, what are its symptoms, causes, diagnosis and treatment.

Giant cell liver disease in newborns Giant liver disease is very rare. According to the International Liver Foundation and the World Health Organization, there are only a few thousand cases of this disease in the world, and only 90% of them are newborns. However, only less than half of cases of GMH are due to hereditary factors, and the rest are due to other causes, such as congenital abnormalities of hepatitis, hepatitis B and C viruses. Although more recent studies have identified mutations in some genes that cause GMH, this form the disease is still not well understood. One of the first studies on giant cell hepatitis was carried out in the 17th century. Several French surgeons, inspired by John Hunter's description, performed liver resections on three infants. They all died. Surgeons later discovered two adult patients with giant livers caused by occlusion of the superior and inferior hepatic veins. Of these, a girl died in 1672, a boy in 1770. Such observations were preserved in 18th-century publications. What's happened