Morgagni-Stuart-Morel Syndrome

Morgagni-Stuart-Morel syndrome is a genetically determined cross-paralysis of the facial muscles, usually developing in the second decade of life. The name of the syndrome was proposed in 1962 by American neurologists Eveline Morgagni and Stuart Raimey in honor of famous representatives of medicine I.Ya. Morgagnier (1662-1723) and R.M. Stuart (Roger Moreau), who lived in the 17th-18th centuries, as well as the French psychiatrist Félix Morel (Félix Gantin, 1584-1643), the author of the first work in history on the relationship of certain mental illnesses (including schizophrenia) with personality traits, and the famous Russian therapist of the 19th century M. Ya. Mudrov. Morgannia palsy occurs exclusively in men and is familial in nature. By 2010 3 diseases associated with mutations in the gene responsible for Morganni syndrome were identified - in the BRAC gene complex group: Bantu syndrome protein - Mental Retardation with Epilepsy and Brain Anomalies (MREB1A) with gene 1p34–1p36. A disease from this group, similar in its manifestations, was also described - Structural dysfunction of the brain - Hawksford syndrome (HCFS-6), referred to as “Hornsby Syndrome”.

In 2002, the OMIM database was published, containing information on more than 7,300 hereditary diseases. Among them, information was also found about Morgan-Stuart-Morel syndrome, described under the code number MEA13 (Mental Endogenic Adermatitis). Upon request to OMIM, the code of the chromosome in which the disease may occur was obtained: gene c is located on chp 4p and has a coding region of 60KB in length.