**Polyfibromatous syndrome** is a disease characterized by the proliferation of fibroblasts in many tissues of the body, which can cause many problems. Common manifestations: tumors, giant cells, skin deformities, fibroids, cancer and scars. The pathology affects a wide range of tissues in the body, including skin, bones, lungs, heart, nerves and eyes. The disease can begin during fetal development, especially if the parents suffer from a chronic lung disease such as tuberculosis or other syndromes. Polyfibrate syndrome appears after birth and progresses through several stages of growth before reaching its peak rate during childhood. The disease is inherited, and no treatment can completely get rid of the symptoms. However, medicine can help slow the progression of hereditary fibromatosis and reduce the risk of other diseases. Surgeries and other interventions can reduce symptoms and help people live normal lives.