Granulomatosis Discoid Progressive Chronic

Granulomatosis discoid progression chronic

Chronic discoid granulomatosis (CDG), or chronic granulomatous erythema (CHG), is an acquired recurrent multifocal inflammation of the skin, the main clinical manifestations of which are remissions and exacerbations of large and small nodular red-brown spots. Typically, the appearance of sharply defined and numerous asymmetrically located small-dermal inflammatory nodules such as granulomas with a subsequent tendency to nexus with a central maternal nodule. The area of ​​compaction, where small granules are released, is bordered by inflamed tissue - bordering. These lesions primarily belong to the pseudosclerokinematoid type with mitotic activity of cells with a predominance of destroyed superstructures, and sometimes borderline changes in the form of warty papules, depigmentation or proustid follicles.

Due to repeated outbreaks of nodular rashes, periodic rashes often occur on the extensor surface of the extremities (particularly large joints) and on the chest and neck, which can persist from 24 to many hours, several days or weeks. The formations appear symmetrically, distal to other areas of the skin on the trunk, shoulders and limbs. A rare mutation

Progressive chronic discoid granulomatosis (syn. progressive granulomatosis and pseudoscleroderatosis) is a rare, chronic granulomatous disease, which is characterized by a slow onset and long course with spontaneous recovery. It is characterized by disc-shaped thickening (erythema) and plaques (granules) of the skin or subcutaneous tissue. A white or yellowish spot appears in the center of the plaque, consisting of neutrophils, Ewing cells and macrophages. Unlike other forms of scleroderma, granulomas never merge (adhesions)