Megalodactyly

Megalodactyla is a rare congenital hereditary disease characterized by pathological growth of the fingers and toes.

This disease was first described in 1985. It is caused by a mutation in the gene that is responsible for the formation of skin and soft tissue. It is inherited in an autosomal dominant manner (from one of the parents).

Initially, the disease was considered isolated, and only in 2003 was the first case identified when this pathology was accompanied by dysplasia of the lower jaw. Thus, we can talk about the complex nature of this disease. It has also been established that patients with megalodactyly often have defects in the forelimbs and fingers, which may also be one of the manifestations of this pathology. It is worth noting that the manifestation of gene deficiency is more often observed in men than in women. In addition, the presence of this anomaly indicates a developmental disorder

"Megalodactyly" is a term used to describe a rare genetic abnormality in which a person develops elongated fingers. This may be due to a malfunction of the gene responsible for tissue growth and development.

There are several types of megalodactyly. The first is a normal increase in the size of the fingers, but at the same time they retain normal shape and function. The second type is a mutation that results in extra joints and soft cartilage inside the big fingers or toes. These fingers can bend in different directions, making movement difficult and painful. The third type of megalodactyly is characterized not only by an increase in size and function, but also by a change in skin color and texture. The skin on the fingers may appear blue, red, or brown, and may feel rough or smooth to the touch. Sometimes this is accompanied by pathological nail growth. The fourth type is a rarer form of megalolactyly, which manifests itself in the form of the formation of additional joints of the toes. This leads to difficulty walking and running due to instability and poor support of the foot. People with this type of disease have an increased likelihood of developing various musculoskeletal diseases, including arthritis, osteoporosis and others. The manifestation of this type of megalolactia in children usually occurs during pregnancy, during examination of the mother. In a pregnant woman, enlarged normal fingers are usually an abnormality. An even rarer, but still existing form of megalolactolini is long fingers due to the deposition of excess calcium in the body. One family is already experiencing several children due to this syndrome, which has been discovered. However, in this child they are more caricature-like, short and thick, and only the surface shows abnormally high amounts of calcium deposits. From this we can conclude that megalolactics is a rare phenomenon.