Osteoporosis Regional

Regional bone osteoporosis (osteoporosis regionalis) is a dystrophic process characterized by a decrease in bone mass and a decrease in its mechanical strength while maintaining body weight.

The main link in the pathogenesis of the process of adaptation to negative influences is the suppressed activity of bone growth factors. Two main factors are involved in the formation of osteoporotic syndrome from the onset of the disease to the formation of residual changes in the bones. These are age and circulatory disorders. Their relationship is confirmed by a pronounced risk factor for the development of osteoporosis in old age and hemodynamic features of microcirculation in young people. In patients with osteoporosis in the early stages, bone tissue deformation does not have clear signs, manifesting itself as compaction of individual areas of bone tissue, followed by the formation of compacted bone nodes, thickening of the cortical layer and narrowing of the bone diameter in the center. Often there is a compensatory expansion of the bone metaphyses with the formation of extensive spongy substance and the formation of bone cysts. Formations of connective tissue replace microfractures of bone tissue until complete dissolution of the bone or its destruction. In patients with chronic abdominal ischemia in the early stages, dense osteodegeneration forms in the form of dense cancellous bone without pronounced hypercalcemic ostosis. In osteoporosis associated with liver disease, osteoporotic bone tuberosities of varying sizes are formed. With rapid development, the formation of small bone-containing tumors of the stromal niche of the spongy bone marrow can be observed. Osteoporotic fractures are most common in the distal tibia, proximal femur, first, second and fourth metatarsals, and rarely in the metaphysis of the humerus. Support when walking is not disturbed. Recurrence of bone fractures is often associated with insufficiency of calcium in the diet and with long-term concomitant use of glucocorticosteroids. Many symptoms of osteopenic syndrome first appear with inflammatory bone diseases. Inflammatory changes in bone tissue appear diffusely and mainly under the influence of a focus of osteoperiostitis or a decompensated fracture, which subsequently structurally disrupts bone tissue over an affected area of ​​more than 2–4 cm3. The tumor density of blood, bone marrow and blood vessels increases, as well as their amplitude of resonant blood flow. A decrease in the magnetic parameters of healthy areas of pericosteal tissue in the area of ​​the destruction boundary is characteristic. With an increase in physical activity, a relative stabilization of physical readiness occurs with manifestations of osteoscintigraphy in lower indicators of relative bone density and reduction