Ranitin-150

Ranitin 150: key points

Ranitine 50 is an inhibitor of H-2 histamine receptors, the mechanism of action of which is to suppress the secretion of acid and pepsin by the parietal cells of the stomach. However, the drug also reduces the permeability of the gastric mucosa, which causes gastrin production and hypergastrinemia. As a result, micro-aggregation and disintegration of parietal cells of the mucous membrane increase, promoting the formation of erosions and gastric ulcers. The combined use of the drug with proton pump antagonists leads to a marked decrease in the amount of circulating gastrins and further suppression of HCl secretion, which promotes the healing of ulcerative lesions of the gastric mucosa. The use of the drug at a dosage of 50 mg exhibits a gastroprotective effect that is not significantly different from that when using placebo, which corresponds to lesser effects of the drug in suppressing the risk of recurrent peptic ulcer disease than higher doses of proton pump inhibitors. In patients with severe dyspepsia in the form of gastroduodenitis associated with NSAIDs, taking ranittin 50 significantly increases the effectiveness of therapy, enhances the effectiveness of anti-inflammatory drugs, restores the pH of the stomach to a less “irritated” state, promotes the growth of symbiotic strains of microflora that are resistant to antibiotics, which are most often associated with Helicobacter pylori infection. The course of use of the drug depends on the severity of the disease, and the minimum period of continuous use is 8 weeks. The pharmacokinetics of the drug is not affected by the dose of NSAIDs. The pharmacokinetics of ranitin is linear, but does not cause accumulation in tissues under long-term use. The maximum concentration of the active substance in the blood is observed after 1-5 hours, the drug is eliminated in 40-60 minutes. In case of systemic renal and hepatic failure, the total clearance (removal of the drug from the body) decreases and T1/2 increases slightly, since liver function is not taken into account.