Agangliosis of the Large Intestine Congenital Segmental

Single section aganglionosis is a congenital malformation that is the absence of ganglia in a single section of the intestine (usually an isolated segment of the colon).

Introduction:

Aganglionosis (aplasia) of single sections of intestinal loops is a rare congenital anomaly of intestinal development. Yeah

Agangliosis (from the Greek ἄ - “not; without” and κύνξ - “dog”), agammaglobulinemia (from the Ancient Greek α - “without” and γλωσσα - “tongue” + Latin globulus - “small ball”, “ tiny"), or Fickhan-Cohen syndrome (English)Russian. - primary chronic monoclonal pathology, in which there is a weakening or loss in a significant part (80–100%) or in the entire population of plasma cells of the production of immunoglobulins or their active transmission by B lymphocytes to T helper cells - the precursors of plasma cells and macrophages, which is accompanied by a noticeable decrease or the disappearance of all classes of immunoglobulin in the blood serum or a decrease in the content of immunoglobulin.

Aganglionosis is a disease of the colon in which the nerve cells located in the wall of the colon - the muscular skeleton layer of the wall - atrophy, as a result of which they poorly transmit signals along the muscle fibers, which leads to stagnation of feces. In most cases of colon aganism, necrosis, paralysis, and malignancy of nerve endings and structures develop.

Causes of aganglionosis include Crohn's disease, heredity (Peutz-Jigers syndrome), colon cancer or other cancers, Epstein-Barr virus, and vitamin K deficiency. Damage to nerve cells can be caused by radiation therapy used to treat cancerous tumors.

Aganglionosis is a dysfunction of the nervous system that can lead to a number of different diseases. In this case we are talking about aganglionosis of the colon. With this disease, the intestines do not have normal nervous control, which can lead to various complications.

Segmental aganglions are very rare in the colon. They arise as a result of the formation of intrauterine infection in the earliest stages of embryogenesis. There are no specific clinical manifestations for this intestinal lesion. Often, the pathology is discovered by chance during an examination for another disease, accompanied by a long period of insomnia.