Aplasia Skin

Aplasia of the skin is one of the forms of congenital malformations of connective tissue, which is based on an abnormal development of the epidermal elements or dermis. The uniformity of the skin depends on the location of pathological elements and their specificity, as well as on the prevalence of aplasia. According to the location of the primary malformation, it is divided into primary, in which the primary defect is the defective development of cells and tissues of the skin, and secondary, associated with defects in the formation of surrounding tissues.

Aplasia is one of the rare skin pathologies in children. The main cause of this defect is considered to be a hereditary factor associated with dysfunction of the Wnt4 and WNT7B gene exchange. This indicates that the patient has a hereditary predisposition to this pathology. Also, the negative impact of harmful environmental factors, such as ionizing radiation, cytostatic substances or chemotherapy, cannot be excluded. Another cause of aplasia is considered to be intrauterine infections,