Holmes-Adie Syndrome

Eydie-Holmes syndrome (also known as Eydie syndrome) is a rare neurological disorder characterized by loss or decreased deep tendon reflexes combined with an abnormal pupillary reflex. Main symptoms include:

1. Decreased or absent deep tendon reflexes, especially in the knee and elbow joints. This occurs due to damage to the sensory fibers of the peripheral nerves.

2. Slow pupil dilation (dilation) when moving from a dark room to bright light. This is called pupillary light response.

3. Slow constriction of the pupil when placed in the dark. This is called pupillary response to darkness.

4. Other possible symptoms include muscle weakness, sensory loss, and autonomic dysfunction.

The exact causes of Eydie syndrome are unknown. It is assumed that it arises from damage to the sympathetic ganglia. It is more common in women aged 20-50 years. Diagnosis is made based on clinical signs. Treatment is usually not required. The prognosis is good, although some symptoms may persist.

Addie Holmes syndrome Addie Holmes syndrome is a rare inherited neurological syndrome characterized by fasciculation syndrome and facial paralysis. It is usually associated with epilepsy and often occurs with stroke and pneumonia. The clinical presentation ranges from mild to severe and is often characterized by movement disorders such as ocular and facial muscle spasms, dystonic progressive nystagmus, and inspiratory stridor. This can lead to the development of delayed psychomotor development in children and cognitive impairment in the future. Treatment of the underlying disease may help alleviate clinical manifestations.