Under-oxidation coefficient

The underoxidation coefficient is one of the parameters that determines the level of iron oxidation in the blood. This parameter is closely related to the condition of the body and can be used to assess overall health.

Discovery of the Muller coefficient In 1909, the German scientist Otto Muller discovered that the human body contains iron, which can be oxidized to compounds with a high oxidation state. He also suggested that the body's iron levels are an important factor in maintaining its metabolism.

Iron-containing enzymes Enzymes are proteins that catalyze chemical reactions in living cells. Iron enzyme systems are a key component of the circulatory system and play an important role in the metabolism and transport of oxygen, carbon dioxide, amino acids and other metabolites.

The relationship between iron oxide levels and human health The coefficient of under-oxidized iron is an indicator of the condition of the body. When iron is in the form of Fe2+, it is called oxidized iron. In contrast, if iron is in a non-passive form (eg Fe3+) or combined with oxygen, it is considered reduced iron, or deoxygenated (iron without oxygen).

Under many conditions, cells optimize energy to accelerate redox reactions, including electron transport, oxidative cycling, and cytochromes. When this mechanism is not yet applied, iron may remain in a deoxygenated form, increasing the iron underoxidation rate.

Why may many people experience increased iron metabolism? One factor that can lead to a high iron underoxygenation ratio is B12 deficiency. B12 is the only essential macronutrient for the formation of the cobalamin complex, a coenzyme needed to convert folic acid into other essential products. A deficiency of this vitamin often leads to deoxygenation of iron, as well as various cognitive impairments.

On the other hand, some medications, such as aspirin and paracetamol, can increase deoxygenic iron levels. In addition, stress conditions, acidosis and other causes can lead to an increase in deoxygenated iron.