Myositis Ossifying Progressive Multiple

Myositis ossificans progressive multiplex (myositis ossificans progressiva multiplex) is a rare hereditary disease characterized by progressive deposition of bone tissue in muscles, tendons and ligaments.

It first appears in childhood at the age of 3-5 years in the form of ossification of the muscles of the back, neck and shoulder girdle. Gradually, the process spreads to other muscle groups, leading to significant limitation of joint mobility and disability.

The causes of the disease are not completely clear. The hereditary nature of the pathology is assumed to be associated with a mutation in the ACVR1 gene.

Diagnosis is based on the clinical picture, X-ray data and biopsy of the affected muscles. Treatment is mainly symptomatic and aimed at maintaining joint function. The prognosis is serious due to the steady progression of the disease.

Ossification myositis is an inflammatory process of skeletal muscles, in which they become denser due to the deposition of inorganic compounds in them. This leads to limited mobility and pain. In children and adolescents, this disease often manifests itself in adolescence, when the body is rapidly growing and developing.