Nephrosis Paraproteinemic

Paraproteinema nephrosis - (n. paraproteinemaica; para- + Greek prōteinēma protein substances) is a form of nephrosis with a peculiar proteinosis, occurring in the form of chronic nephrotic syndrome. It is observed almost exclusively in men, who call these diseases “silent death”.

Symptoms of this disease in the initial stages may be absent or only mildly manifested. General weakness, fatigue, weight loss, pain in the lumbar region, and in men, potency is severely impaired. The course of the disease is very slow and is characterized by a constant increase in symptoms.

Over a long period of time, tolerance to penicillin and cephalosporins develops. Month-long temperature fluctuations are typical. Intoxication gradually increases, which leads to cerebral phenomena, bradycardia, venous congestion, edema and tissue infiltration (including ascites). Possible heart rhythm disturbances and heart failure. Sometimes hemorrhages (petechiae, ecchymosis) appear on the skin, mucous membranes of the mouth and esophagus, as well as nosebleeds. The skin loses elasticity, swells, the skin tone becomes yellowish-brown, and often crater-shaped rashes appear on it in the form of castings, reminiscent of mycotic ulcers. Brownish-purple spots on the cheeks and neck that patients call “liver kisses.” The mucous membranes are also affected, the colored areas acquire a brick-red color due to the formation of iron compounds. Possible damage to internal organs, encephalopathy, dementia, parapsy, tendency to collapse and uremia. The progression of the disease is quite slow, but in most cases patients die from uremic coma. Sometimes it is possible to recover and remain functional. It should be understood that the treatment of nephrosis includes extensive therapeutic measures, which may differ depending on the form of the disease, the conditions of its course and the individual characteristics of the patient.