Crab Roasts

Accounts for 1-1.5% of all malignant tumors. Hepatocellular cancer develops most often (90%), less often - cholangiocellular cancer (10%). The development of liver cancer can occur with or without previous cirrhosis.

Clinical symptoms vary depending on this. If, against the background of signs of liver cirrhosis, there is a sharp deterioration in the general condition, rapid loss of body weight, pain in the right hypochondrium, an increase in laboratory signs of liver dysfunction, the appearance of ascites, and the size of focal formations changes according to ultrasound tomography, it is reasonable to assume liver cancer. In other cases, against the background of a favorable general condition, an enlarged liver is detected upon palpation, and ultrasound and computed tomograms reveal a large tumor with or without small formations (nodular form).

Sometimes a large node is not detected (diffuse form). As the disease progresses, intra-abdominal bleeding, jaundice, ascites, and other symptoms may develop. The diagnosis of liver cancer is made by tumor biopsy (percutaneous, laparoscopic).

It is important to determine a-fetoprotein in the blood, the level of which in hepatocellular cancer is high in 70-90% of patients. The extent of the spread of the disease is also determined by angiography. Differential diagnosis is made with metastatic cancer.

Liver cancer metastases occur within the organ, less commonly (30-50%) in the periportal lymph nodes, lungs, and bones.

Treatment. For localized liver cancer, liver resection is performed. The five-year survival rate averages 15-30%, the best results are obtained with well-differentiated cancer. Temporary objective and subjective improvement is provided by ligation or embolization of the hepatic artery. Improvement is also observed with chemotherapy administered through the hepatic artery (5-fluorouracil, Adriamycin, mitomycin C) or systemically intravenously using combinations of Adriamycin - 50 mg/m2 on the 1st day and 5-fluorouracil - 600 mg/m2 on the 1st day and 8th days; carminomycin - 18 mg/m2 on the 1st day and bleomycetin - 10-15 mg every other day, 5 doses.