Riley-Day Syndrome (S. M. Riley; R. L. Day; Syn. Riley-Day Familial Autonomic Dysfunction)

Riley-Day Syndrome: an inherited combination of symptoms

Riley-Day syndrome, also known as Familial Autonomic Dysfunction, is an inherited syndrome that is characterized by a combination of several symptoms. It was first described in 1949 by S. M. Riley and R. L. Day, and was named after them.

This syndrome manifests itself in a combination of hypersalivation, decreased lacrimation, erythema, mental lability, hyporeflexia and decreased pain sensitivity. These symptoms can occur in varying degrees of severity and vary depending on the individual case.

There are many scientific studies that are trying to understand the causes and mechanisms of this syndrome. However, at the moment, the exact mechanisms of its appearance are not known. What is known is that the syndrome is inherited in an autosomal recessive manner, which means that two copies of the gene responsible for the development of this syndrome must be inherited - one from each parent - for this pathology to manifest itself.

Additionally, there are certain measures that can help improve the quality of life of people suffering from this syndrome. For example, it is important to maintain oral hygiene to prevent complications associated with hypersalivation. It is also necessary to undergo regular medical examinations to monitor the development of other diseases.

In conclusion, Riley-Day syndrome is an inherited syndrome that manifests itself in a combination of several symptoms. Although the exact mechanisms behind its occurrence are unknown, there are certain measures that can help improve the quality of life of people suffering from this syndrome.

**Riley-Dey syndrome** (S. M. Riley; R L. Day) is a hereditary disorder that manifests itself with various symptoms, including increased salivation, decreased tear production, erythrema, mental lability, hyporeflex, and decreased pain sensitivity. This syndrome is inherited in a recessive manner, that is, it appears only in carriers of both alleles of the genetic marker responsible for this disorder.

This disorder was first described in 2013 by English physician Samuel Riley and American otolaryngologist Robert Lee Day. They indicated that a familial history of this disorder included multiple family members who exhibited common symptoms. Further research discovered a genetic marker for this disorder, which was later named the Riley–Dey genetic marker.

Riley-Day syndrome is characterized by hereditary inheritance of the disorder based on a recessive marker. This means that the parents should not have even one copy of a given genetic gene. Each of them must have one normal gene and one mutant in order to pass on the gene to the child. If they have both normal genes, these two genes compensate each other and the child is born healthy, usually without any hereditary disorders.

The symptoms of Riley Day syndrome depend on the specific combination of genes that are responsible for the disorder. However, some people may have several symptoms of the syndrome, while others may have only one or two. Symptoms of Riley-Day syndrome include: - Hypersalivation (increased salivation) - Decreased lacrimation (compared to average normal lacrimation) - Erythrema (dilation of blood vessels in the skin, called erythema, is a common sign of the syndrome) - Psychiatric laxity