Acrokeratosis Warty

Article Acrokeratotic verrucous syndrome

Introduction

Acrokeratotic wart syndrome (AKWS) is a hereditary pathology characterized by the formation of specific plaques and warts on the skin of the palms, soles, feet and, less commonly, on other areas of the skin. This disease has a chronic course, but can lead to severe complications and even disability. This article will discuss the etiology, clinical picture, diagnosis and treatment of ACHD.

The etiology of ACHD is unknown, but factors that may contribute to the development of the disease have been identified:

1. Genetic factors: confirmed by the presence of a deletion in the gene encoding epidermal keratinase protein 6 (FKRP) in patients with ACHD, indicating a possible role of this gene in the development of the disease. However, the localization of the gene itself still remains unknown. 2. Mutations in other genes can also cause ACHD - for example, the TGM6 gene, which encodes the transglutaminase protein, may be involved in the genesis of a severe form of acronyachylia

Acrokeratosis is called keratinization of the skin of the feet in children during adolescence. It is because of this lesion that the child’s musculoskeletal system can sometimes be impaired. The disease is very rare, occurring in only one child in fifty thousand; often causes complications. It is detected mainly in boys. According to the clinical picture and symptoms, acrokeratoses are distinguished into two types: warty and benign dyskeratotic and acute miliary.

Acrokeratosis warty (Hopf-verrucosis, English acrokerato-sis verruc-formis, X-lenticulo-atrophic kerato-dermitosis of Por-tals - Port's keratodermitoscleroderma) is a genetically heterogeneous group of skin diseases, which is based on a generalized lesion of the stratum corneum with varying degrees of hyperkeratosis (“wartiness”) and atrophic changes