Bourneville-Pringle Disease

Bourneville-Pringle disease

Bourneville-Pringle disease is a rare genetic disease characterized by the formation of benign tumors in various organs.

This disease was first described by the French neurologist Désiré-Magloire Bourneville and the English pediatrician John James Pringle in 1880, which is why it is also called Bourneville-Pringle disease.

The main symptoms of Bourneville-Pringle disease:

1. The formation of hamartomas (benign tumors) in various organs - the brain, skin, eyes, lungs, kidneys and others.

2. Epileptic seizures caused by the presence of brain tumors.

3. Intellectual and behavioral disorders.

4. Skin manifestations in the form of hypopigmented spots.

The cause of the disease is mutations in the TSC1 and TSC2 genes, leading to dysregulation of cell growth and reproduction.

Treatment consists of surgical removal of tumors and correction of associated disorders. The prognosis is generally favorable, but the course of the disease can be severe due to multiple tumors in vital organs.

Bourneville-Prignle disease (BPD, from the English Boum eville and Prignle Disease) is a rare chronic disease associated with increased sensitivity to stimuli from the outside world. It is characterized by a change in a person’s mental state under the influence of any stimulus. This disease can lead to severe emotional and psychological changes, including anxiety, depression, aggression and even paranoia.

The main symptom of Bourneville-Prigo disease is irritability, which can manifest as impulsiveness, moodiness, and unpredictability of behavior. A person with BPD may feel a constant need for novelty that they try to satisfy despite possible negative consequences. He may have changeable moods, attacks of aggression, jealousy and anger. In turn, the person may also experience depression, anxiety and apathy. Moreover, the syndrome does not appear immediately, but only after a certain period of time and is difficult to identify. It is possible that symptoms may only develop over time.

But that's not all... A person diagnosed with BPD may suffer from a number of symptoms that have nothing to do with external factors. For example, he may have nightmares and develop hallucinations.