Myocarditis Transplantation

The article "Transplantation myocarditis - m e transplantatione" about transplantation myocarditis is a condition in which heart tissue is temporarily or permanently damaged by a transplanted heart from another organism. This can lead to unpredictable consequences for the person with a heart transplant. In this article we will look at the main causes of transplant myocarditis, as well as the possible consequences and treatment of this disease.

Myocarditis is an inflammatory lesion of the myocardium, its lower and upper walls and the interventricular septum; according to some classifications - only the lower wall. Inflammation of the heart muscle resulting from viral or bacterial damage to the myocardium

Myocarditis Transplantation (hereinafter referred to as M.T.) is an inflammatory disease of the heart muscle that occurs during the first 3 months after heart transplantation. It occurs in approximately 2% of patients and is one of the most serious complications of heart transplantation, leading to transplant failure and death.

Last year M.T. became the main obstacle on the way to a record achievement - the first successful human heart transplant to a person. Heart transplantation is one of the most difficult and risky treatments for heart disease. It allows you to replace the damaged myocardium with the healthy heart of another person or animal. However, due to the characteristics of the body and the specificity of the immune system, failure of the host's immune cells can lead to severe complications such as M.T., which can develop in the first weeks after transplantation.

Symptoms of M.T.: palpitations, swelling, fever, weakness. Late manifestations may include pulmonary vascular damage, arrhythmias, cardiac arrhythmias, and shortness of breath. If such symptoms appear, immediate medical attention is required. They can appear within a month after transplantation or several years later.

Often, M.T develops against the background of graft-versus-host disease. However, it is now not entirely clear why this reaction occurs, and most researchers believe genetic factors. The contribution of immunosuppressive drugs, the duration of the operation, the waiting time before transplantation, and the presence of a viral infection are also considered. Taking into account all these factors, it is customary to separate acute myocardial inflammation from complications of the early phase. Such a complication is M. T. Early manifestations include fever, pain on palpation; the later ones are characterized by inflammatory systolic murmur, arrhythmia, and exudative pleurisy.

Drugs for the treatment of M.T.: cytostatics such as methotrexate, cyclosporine A, tacrolimus and mycophenolate mofetil. Cyclosporine reduces the likelihood of developing M.T., although it can also cause other complications such as nephropathy

Myocardial transplant syndrome refers to coronary heart disease caused by rejection of a new heart after heart transplantation. Occurs as a complication in repeat heart transplant patients who have chronic rejection reactions or are allergic to certain immunosuppressants. Often observed in patients receiving radioisotope therapy (radium-223\), inter