Nephritis Malignant Subacute

Malignant infraspinous nephritis affects the lobules of renal tissue in the form of individual micronecrosis, which are visible during histological examination. At the beginning of the process, exudation predominates, which then gives way to proliferation, leading to the replacement of the necrotic tissue area, which changes the architectonics and increases the degree of functional failure of the kidney. The process involves the entire kidney and leads to its shrinkage. Granular ciliary masses from the exudate first fill the epithelial tubules and are then forced out by cylinders. Fibrous cords subside, metanephromes disappear, and at the same time the amount of colloids in the tubules and interstitium increases. The amount of proteins in the blood increases, hypoglobulinemia, macrocytopoiesis, hyperlipidemia, and positive immunological tests appear. Bacteria in the kidneys are absent or found in small numbers in the periglomerular zone. The clinical picture of the onset of the disease is similar to interstitial